Pulmonary benign metastasizing leiomyoma

Lamiae Amaadour, Nawfel Mellas

PAMJ. 2021; 39:68. Published 25 May 2021 | doi:10.11604/pamj.2021.39.68.29152

Pulmonary benign metastasizing leiomyoma (PBML) is a rare hormone dependent disease that refers to benign hysteromyoma metastasizing to the lung. Lung biopsy is indispensable for the diagnosis for PBML. Therapeutic options include surgical removing of the tumor, hormonal therapy (hysterectomy, bilateral adnexectomy, and long term oral drugs such tamoxifene, raloxifene, and aromatase inhibitors), and inferior vena cava filter implantation. A 57 years old postmenopausal woman underwent total hysterectomy for uterine leiomyoma. Eight years later, she presented with a chronic cough and dyspnea. A thoracic computed tomography scan showed a solitary proximal nodule of 4 cm on the right lung (A). Histological examination of biopsies revealed a benign leiomyoma of the lung. As the surgery would be mutilating, a regular follow up was recommended but she lost sight of. The patient was lost of view for one year before she appears with increased cough, dyspnea and chest pain. A new CT-scan showed a significant increase in size of the initial tumor of about 4 cm with compression of the right bronchus (B). Subsequently, biopsies have been performed as a leiomyosarcomatous transformation has been suspected. Histopathological analysis disclosed the diagnosis of a benign metastasizing leiomyoma of the lung. The patient was given the aromatase inhibitor (Letrozole 2.5 mg). This treatment yielded a disease progression after six months. Second line Tamoxifene was then started. The disease is still stable for 19 months now and the patient will continue to be followed.
Corresponding author
Lamiae Amaadour, Department of Medical Oncology, Hassan II University Hospital of Fez, Faculty of Medicine, University Sidi Mohamed Ben Abdellah, Fez, Morocco (lamiae.amaadour@gmail.com)

The Pan African Medical Journal (ISSN: 1937-8688) is a subsidiary of the Pan African Medical Journal. The contents of this journal is intended exclusively for professionals in the medical, paramedical and public health and other health sectors.

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