Continuous external compression for the treatment of humeral pseudarthrosis: a single center experience

Continuous external compression for the treatment of humeral pseudarthrosis: a single center experience

Sami Sallemi¹, Nizar Sahnoun^1,&, Mahdi Maatoug¹, Moez Trigui¹, Imen Zouch², Mariem Keskes², Ameur Abid¹, Hassib Keskes¹

 

¹Department of Orthopedic Surgery and Traumatology, Habib Bourguiba University Hospital, Sfax, Tunisia, ²Department of Anesthesia, Habib Bourguiba University Hospital, Sfax, Tunisia

 

 

^&Corresponding author
Nizar Sahnoun, Department of Orthopedic Surgery and Traumatology, Habib Bourguiba University Hospital, Sfax, Tunisia

 

 

 

 

Humeral shaft fractures represent 1% of skeletal fractures, with a high rate of bone healing. However, unfavorable evolutions are not exceptional, and humeral pseudarthrosis ranges from 8% to 13% [1,2]. Several operative methods were described in the literature for treatment of humeral shaft pseudarthrosis. The dynamic external fixation with bone graft is classically used [3]. The objective of this paper was to assess the evolution of patients with humeral pseudarthrosis who underwent external continuous compression without bone grafting.

 

 

This study was conducted in the orthopedic surgery department in Habib Bourguiba hospital in Sfax, Tunisia. It involved 58 cases with humeral pseudarthrosis, treated between April 2009 and September 2018 with a minimum follow up of 12 months. All the patients were operated on with the same surgeon, and using the same technique of dynamic monoplane axial fixation device in continuous compression by manipulating the compression system of the fixator. The location of the non-union concerned the humeral diaphysis under the lower edge of the large pectoral insertion and above the epicondylar crest. Fracture type was evaluated according to the AO classification. We evaluated our results according to the modified Stewart and Hundley classification [4] ( Table 1).

 

 

The average age of the patients was 42 years with extremes ranging from 17 to 77 years. The distribution by sex showed a clear predominance of men that represented 41 cases (70.7%) with a ratio of 2.4. The circumstances of occurrence were dominated by traffic accidents which caused 46.6% of cases. The fracture was located in the diaphyseal middle third in 53.4% of the cases and in the distal third in 46.6%. The fracture type was a simple type A in 75.9% of the cases, type B in 19%, and complex type C in 5.1%. In simple fractures, the line was transverse (A3) in 55.2% of the cases. We found 34.5% hypertrophic, 43.1% atrophic and 22.4% oligotrophic non-unions. Initially, the fracture underwent orthopedic treatment in 15.5% of the cases, an intramedullary bundle nailing in 53.4%, by screwed plate in 19% and by Hoffmann type external fixator in 12.1%. Fifty-four patients were treated with continuous external compression as a first cure of non-union and four patients had previously a first cure for their pseudarthrosis and were treated with this method after the failure of the first cure. Good alignment and bone contact were checked with intraoperative radioscopy. The average recovery period was 47.2 months, with extremes ranging from 12 to 102 months. We obtained a consolidation for 98% of the pseudarthrosis (Figure 1). Only one case did not consolidate, including a sepsis on the pins. The average consolidation time was 5.1 months with extremes ranging from 2 to 10 months (Table 2). We noted 11 sepsis on pins, 10 of which evolved well after antibiotic treatment. There were no neurological complications, or algodystrophy. Based on the modified Stewart and Hundley criteria, we found 75.8% of very good results, 17.2% of good results, 5.2% of fairly good results, and 1.8% of poor result (Figure 2).

 

 

Compression is the principle adopted in our surgical procedure for the non-union of long bones. Using a compression plate is the only technique allowing a good stabilization of the non-union, while performing a bone graft is essential for consolidation. However, in this type of treatment, bone graft seems to play a crucial role. Healy et al. [5] reported 45% of failures by screwed plates without bone graft. Moreover, several articles reported that consolidations could only be obtained by grafting without any modification of the osteosynthesis. Interestingly, the isolated graft supply partly explains the excellent results on non-union cures by plate, bone graft sometimes being considered as an "adjuvant" to the treatment already carried out [6]. Also, we obtained a 98% consolidation rate with the use of screwed plate associated with spongy graft as shown in Table 3 [3,5-11]. Centromedullary nail fixation preserves periosteal vascularity and decreases the rate of radial paralysis and infection. However, this technique is controversial due to the high rate of failure according to several studies as displayed in Table 4 [8,12-15].

 

Several hypotheses could explain these failures, like the insufficiency of primary stability or the impairment of the endomedullary vascularization of the humerus [14]. The Ilizarov external fixator should allow stable fixation, possible correction of the reduction and compression of the pseudarthrosis site [16,17]. Table 5 shows the good consolidation rate of the Ilizarov device [17-19]. Ilizarov external fixator preserves the periosteum vascularization. However, this method is associated with a significant rate of complications including stiffness, iterative fractures after removal of the fixator, nerve damage (axillary nerve on the proximal pins or of the radial nerve on the distal pins) and the very bulky material. The consolidation rate is around 90% in 6 months with 10% disabling stiffness in the shoulder or elbow. We adopted the principle of compression by external fixation inspired by Ilizarov data on the confrontation of the edges of the non-union, crushing of the interposing tissues, creation of micro fractures, local necrosis of the interposed fibro-cartilaginous tissues, inflammation and thus an influx of polynuclear cells, and osteoclasts followed by osteoblasts, thus initiating osteogenesis [20,21]. Monoplane external fixator in compression allowed a minimal unilateral exposure at the non-union site, minimal surgical trauma to the soft tissue, an easy application of the fixator and consecutively minimal blood loss and a short operating time [22]. This technique was first described in 2001 by Lavini F et al. [23] about 27 aseptic pseudarthrosis of the humerus but associated in 26 cases with bone graft. Only one case was treated by simple compression without opening the site. The consolidation rate was 92.5% within a period of 4.9 months. No major complications were observed (radial paralysis, joint stiffness, or deep infection). For Atalar AC et al. [24], 24 patients were treated with an external monoplane fixator in compression, with bone graft for all patients. The consolidation rate was 95.8%, within a period of 5.2 months. In our series, 58 patients were treated with an external monoplane compression fixator. No cortico-spongy graft was made. The opening of the site was only necessary in 43.1% of the cases. The consolidation rate was 98%, within an average time of 5.1 months.

 

Compared to the literature, the treatment of humeral non-union by monoplane external fixation with compression reduces the operating time, minimizes bleeding and avoids bone grafting and vascular-nerve complications. It also reduces the duration of hospitalization while obtaining very satisfactory anatomical and functional results, whatever the type of non-union. The study shows that the use of an external compression fixation in the treatment of humeral pseudarthrosis allows their consolidation without opening the pseudarthrosis site and without bone graft. Compression was shown to allow the necrosis of the interposition tissues and the bone contact associated with a stable fixation. These conditions could be maintained throughout the treatment by the possibility of secondary compression during follow-up. The opening of the pseudathrosis site is only necessary for removal of material or for radial nerve neurolysis. The only limit to this technique is sepsis on pins.

 

 

The treatment of humeral pseudarthrosis with monoplane external fixator with compression seems effective regarding the low incidence of complications and the high rate of bone healing. This method is a good indication in the treatment of humeral pseudarthrosis and probably long bone pseudarthrosis in general.

 

 

The authors declare no competing interests.

 

 

Sahnoun N and Sallemi S have participated in all phases of this study during proposal preparation, data collection, data analysis and manuscript writing; Matoug M and Trigui M contributed in the manuscript revision with an additional of work supervision done by Zouch I and Keskes M. Keskes H and Abid A also reviewed the manuscript. All the authors have read and agreed to the final manuscript.

 

 

Table 1: the modified Stewart and Hundley classification

Table 2: consolidation time (months)

Table 3: evaluation of the patients according to the modified Stewart and Hundley criteria

Table 4: results of the treatment of non-union with nail

Table 5: results of the treatment of non-union with an Ilizarov type external fixator

Figure 1: example of a case of consolidation of humeral pseudarthrosis

Figure 2: evaluation of the patients according to the modified Stewart and Hundley

 

 

1. Leiblein M, Verboket R, Marzi I, Wagner N, Nau C. Nonunions of the humerus-Treatment concepts and results of the last five years. Chin J Traumatol. août 2019;22(4):187-95. PubMed | Google Scholar


2. Martínez AA null, Herrera A, Pérez JM, Cuenca J, Martínez J. Treatment of humeral shaft nonunion by external fixation: a valuable option. J Orthop Sci. 2001;6(3):238-41. PubMed | Google Scholar


3. Singh AK, Arun GR, Narsaria N, Srivastava A. Treatment of non-union of humerus diaphyseal fractures: a prospective study comparing interlocking nail and locking compression plate. Arch Orthop Trauma Surg. juill 2014;134(7):947-5. PubMed | Google Scholar


4. Stewart MJ, Hundley JM. Fractures of the humerus; a comparative study in methods of treatment. J Bone Joint Surg Am. juill 1955;37-A(4):681-92. PubMed | Google Scholar


5. Healy WL, White GM, Mick CA, Brooker AF, Weiland AJ. Nonunion of the humeral shaft. Clin Orthop Relat Res. juin 1987;(219):206-13. PubMed | Google Scholar


6. Chantelot C, Ferry S, Lahoude-Chantelot S, Prodomme G, Guinand R, Fontaine C. Étude rétrospective des résultats du traitement chirurgical de 21 pseudarthroses de l'humérus. Chirurgie de la main. Avril 2005;24(2): 84-91. Google Scholar


7. de Dompsure RB, Peter R, Hoffmeyer P. Non-consolidation aseptique de la diaphyse humérale. Revue de 21 patients traités par décortication, plaque en compression et autogreffe osseuse. Revue de Chirurgie Orthopédique et Traumatologique. Avril 2010;96(2): 183-190. Google Scholar


8. Loomer R, Kokan P. Non-union in fractures of the humeral shaft. Injury. 1 janv 1975;7(4):274. PubMed | Google Scholar


9. Müller ME. Treatment of nonunions by compression. Clin Orthop Relat Res. déc 1965;43:83-92. PubMed | Google Scholar


10. McKee MD, DiPasquale DJ, Wild LM, Stephen DJG, Kreder HJ, Schemitsch EH. The effect of smoking on clinical outcome and complication rates following Ilizarov reconstruction. J Orthop Trauma. déc 2003;17(10):663-7. PubMed | Google Scholar


11. Wu CC, Shih CH. Treatment for nonunion of the shaft of the humerus: comparison of plates and Seidel interlocking nails. Can J Surg. déc 1992;35(6):661-5. PubMed | Google Scholar


12. Dujardin FH, Mazirt N, Tobenas AC, Duparc F, Thomine JM. Failure of locked centro-medullary nailing in pseudarthrosis of the humeral diaphysis. Rev Chir Orthop Reparatrice Appar Mot. déc 2000;86(8):773-80. PubMed | Google Scholar


13. McKee MD, Miranda MA, Riemer BL, Blaser RB, Redmond BJ, Sims SH et al. Management of humeral nonunion after the failure of locking intramedullary nails. J Orthop Trauma. 1996;10(7):492-9. PubMed | Google Scholar


14. Pietu G, Letenneur J, Bourgade M. The Seidel humeral nail in limited indications: pathological fractures, delayed union, pseudarthrosis and reconstruction. Acta Orthop Belg. 1994;60(2):187-93. PubMed | Google Scholar


15. Wu CC. Humeral shaft nonunion treated by a Seidel interlocking nail with a supplementary staple. Clin Orthop Relat Res. mai 1996;(326):203-8. PubMed | Google Scholar


16. Tomic S, Bumbasirevic M, Lesic A, Mitkovic M, Atkinson HDE. Ilizarov frame fixation without bone graft for atrophic humeral shaft nonunion: 28 patients with a minimum 2-year follow-up. J Orthop Trauma. sept 2007;21(8):549-56. PubMed | Google Scholar


17. Raschke M, Khodadadyan C, Maitino PD, Hoffmann R, Südkamp NP. Nonunion of the humerus following intramedullary nailing treated by Ilizarov hybrid fixation. J Orthop Trauma. févr 1998;12(2):138-41. PubMed | Google Scholar


18. Patel VR, Menon DK, Pool RD, Simonis RB. Nonunion of the humerus after failure of surgical treatment. Management using the Ilizarov circular fixator. J Bone Joint Surg Br. sept 2000;82(7):977-83. PubMed | Google Scholar


19. Lammens J, Bauduin G, Driesen R, Moens P, Stuyck J, De Smet L et al. Treatment of nonunion of the humerus using the Ilizarov external fixator. Clin Orthop Relat Res. août 1998;(353):223-30. PubMed | Google Scholar


20. Ilizarov GA. Clinical application of the tension-stress effect for limb lengthening. Clin Orthop Relat Res. janv 1990;(250):8-26. PubMed | Google Scholar


21. Decoulx P, Razemon JP. [Treatment of diaphysial pseudarthrosis with Danis coaptor]. Mem Acad Chir (Paris). 5 févr 1958;84(4 5):134-8. PubMed | Google Scholar


22. Micic ID, Dragoljub MI, Mitkovic MB, Borivoje MM, Mladenovic DS, Svetomir MD et al. Treatment of the humeral shaft aseptic nonunion using plate or unilateral external fixator. J Trauma. mai 2008;64(5):1290-6. PubMed | Google Scholar


23. Lavini F, Renzi Brivio L, Pizzoli A, Giotakis N, Bartolozzi P. Treatment of non-union of the humerus using the Orthofix external fixator. Injury. déc 2001;32 Suppl 4:SD35-40. PubMed | Google Scholar


24. Atalar AC, Kocaoglu M, Demirhan M, Bilsel K, Eralp L. Comparison of three different treatment modalities in the management of humeral shaft nonunions (plates, unilateral, and circular external fixators). J Orthop Trauma. avr 2008;22(4):248-57. PubMed | Google Scholar