Primary squamous cell carcinoma of endometrium: case report and literature review

Primary squamous cell carcinoma of endometrium: case report and literature review

Fatima Zahra Farhane^1,&, Zineb Alami¹, Touria Bouhafa¹, Abderrahmane Elmazghi¹, Khalid Hassouni¹

 

¹Service de Radiothérapie, CHU Hassan II Fès, Maroc

 

 

^&Corresponding author
Fatima Zahra Farhane, Service de Radiothérapie, CHU Hassan II Fès, Maroc

 

 

 

 

Pure primary endometrial squamous cell carcinoma (PESCC) are extremely rare, accounting for 1 % of all malignancies of the corpus uteri. Since the first report published by Gebhard in 1892, only few cases of PESCC have been published. Here, we report a case of PESCC.

 

 

A 64-year-old woman, Gravida 5 Para 5, was admitted because postmenopausal bleeding. The gynecological exam found bleeding from the endocervix, uterus had normal size without mass or laterouterine sensitivity. The pelvic ultrasound objectified uterine regular contours, mesuring 103/70 mm, endometrial thickened was 10 mm, the presence of an intra cavitary vascular Doppler lesion mesuring 56/70 mm. The diagnostic hysteroscopy revealed a whitish appearance taking all the uterine cavity making evoke a tumor of the endometrium. Pelvic MRI showed a tumor limited to the uterine corpus endometrium (invasion by more than 50% of the myometrium) without invasion of the cervix. Radical hysterectomy, bilateral salpingo-oophorectomy, and lymph nodes dissection were performed. Grossly, the endometrial carcinoma was polypoid tumor occupying the entire uterine cavity. Histologically, the diagnosis of SCC was retained (Figure 1). No adenocarcinoma element was recognized. Neither squamous metaplasia nor dysplasia was recognized. No ectopic cervical tissue was found. The SCC was found to invade into deeper one half of the myometrium. No tumor cells were seen in other sites including the cervix, ovaries, parametres, and lymph nodes. The patients was FIGO 200 stage IB (pT1B, N0), and was treated with adjuvant radiation. The patient had a disease progression in the pelvis 3 months after the irradiation.

 

 

Pure primary endometrial squamous cell carcinoma (PESCC) are extremely rare, accounting for <1 % of all malignancies of the corpus uteri [1]. In the literature, fewer than 100 cases were reported since the first report in 1892 by Gebhard [2]. Diagnosis of PESCC is based on Fluhmann criteria (1928). Briefly, it is mandatory to exclude: cervical carcinoma involving the endometrium, coexistent endometrial adenocarcinoma, and contiguity between the endometrial cancer and the squamous cervix epithelium [3]. The etiopathogenesis of PSCCE is still unknown because of its rarity [4]. Accurate revision of the literature revealed that diverse and controversial hypotheses were suggested by some researchers to clarify causes and pathogenetic mechanisms responsible for PSCCE. In 1993, Horn and Bilek [2] suggested that this malignancy could be the result of a bidirectional differentiation of pluripotent endometrial precursor cells. In 1995, Yamamoto et al. [5] in a case report emphasized that PSCCE may arise from heterotropic cervical tissue. More recently, some authors probed to establish if PSCCE could be correlated to human papilloma virus (HPV) infection. The results of these studies are controversial, too. Some authors, in fact, did not detected HPV in cases of PSCCE by in situ hybridization and thus concluded that HPV infection may not be a carcinogenic factor in the development of this neoplasm [6]. Kataoka et al. [7] by polymerase chain reaction (PCR) instead demonstrated the presence of human papilloma virus (HPV) type 31 and the absence of mutation of tumorsuppressor gene p53.

 

The clinical features of PSCCE were reported by Goodman et al. [8], who found eight cases of this rare neoplasm in a review of 1182 patients treated for endometrial cancer at the Massachusetts General Hospital and 56 cases described previously in literature. The neoplasm occurred in menopausal and postmenopausal women. The factors predisposing to the development of PSCCE included pyometra, pelvic radiation, estrogen deficiency, and estrogen excess [8]. The main clinical manifestations of PSCCE were postmenopausal bleeding, vaginal discharge, pain, weight loss, and pelvic mass. The distant metastases were observed in urethral meatus, vaginal orifice, peritoneal surface, lung, liver, and brain [8]. The average age of women with ESCC, 67 years, is older than the 60 years for patients with corpus carcinoma in general [8]. Molecular alterations in PSCCE leading to cell cycle dysregulation are incompletely investigated. Bures et al. [9] reported in a study of 5 cases of PSCCE investigating molecular alterations leading to cell cycle dysregulation, that the PSCCE has molecular alterations involving the pRB-Cyclin D1-CDK4/6-p16 pathway, and pTEN. (Bures) And In contrast to the type I Endometrioid adenocarcinoma of the endometrium, PSCCE is not hormonally sensitive, suggesting a unique pathogenesis [9]. Given the rarity of this condition, there is no consensus for the best way to manage these patients with PSCCE [10]. Many different treatment options have been reported in the literature: surgical resection with or without adjuvant chemotherapy/radiotherapy [10]. Survival data of patients affected by PESCC are scarce and controversial. The few available data suggest that these malignancies have a mixed behavior resembling both endometrial and cervical cancer [1]. For this reason women with early-stage disease have a favorable prognosis, whereas in case of locally advanced cancer, survival is generally poor [1].

 

 

Pure primary endometrial squamous cell carcinoma (PESCC) is an extremely rare malignancie of the corpus uteri. Diagnosis of this rare entity is based on careful pathologic review of the hysterectomy specimen. The underlying etiology or inciting factors leading to this condition have yet to be determined. More studies are needed to address the concern about the extension of primary surgical treatment and the efficacy of adjuvant therapy in this disease.

 

 

The authors declare no competing interests.

 

 

All authors read and approved the final version of the manuscript.

 

 

Figure 1: primary squamous cell carcinoma of endometrium

 

 

1. Giorgio Bogani et al. Primary squamous cell carcinoma of the endometrium in elderly women: a report of four cases. Aging Clin Exp Res. 2014 Oct; 26(5):543-5. Google Scholar


2. Horn LC, Bilek K. Primary squamous cell carcinomas of the endometrium: clinico-pathologic data and histogenetic classification. Zentralbl Pathol. 1993 Nov;139(4-5):355-60. PubMed | Google Scholar


3. Thomakos N, Galaal K, Godfrey KA, Hemming D, Naik R, Hatem MH, Lopes A. Primary endometrial squamous cell carcinoma. Arch Gynecol Obstet. 2008 Aug;278(2):177-80. PubMed | Google Scholar


4. Giordano G, D'Adda T, Merisio C et al. Primary squamous cell carcinoma of the endometrium: a case report with immunohistochemical and molecular study. Gynecol Oncol. 2005 Mar; 96(3):876-9. PubMed | Google Scholar


5. Yamamoto Y, Izumi K, Otsuka H, Kishi Y, Mimura T, Okitsu O. Primary squamous cell carcinoma of the endometrium: a case report and a suggestion of new histogenesis. Int J Gynecol Pathol. 1995; 14(1):75-80. PubMed | Google Scholar


6. Im DD, Shah KV, Rosenshein NB. Report of three new cases of squamous carcinoma of the endometrium with emphasis in the HPV status. Gynecol Oncol. 1995 (Mar); 56(3):464- 9. PubMed | Google Scholar


7. Kataoka A, Nishida T, Sugiyama T, Hori K, Honda S, Yakushiji M. Squamous cell carcinoma of the endometrium with human papillomavirus type 31 and without tumor suppressor gene p53 mutation. Gynecol Oncol. 1997; 65(1):180-4. PubMed | Google Scholar


8. Goodman A, Zukerberg L, Rice LW, Fuller AF, Young RH, Scully RE. Squamous cell carcinoma of the endometrium: a report of eight cases and a review of the literature. Gynecol Oncol. 1996; 61(1):54-60. PubMed | Google Scholar


9. Nicole Bures et al. Primary squamous cell carcinoma of the endometrium: clinicopathologic and molecular characteristics. Int J Gynecol Pathol. 2013 Nov; 32(6):566-75. Google Scholar


10. Goodrich S, Kebria-Moslemi M, Broshear J et al. Primary squamous cell carcinoma of the endometrium: two cases and a review of the literature. Diagn Cytopathol. 2013 Sep;41(9):817-20. PubMed | Google Scholar