Acute cholecystitis as a rare presentation of metastatic breast carcinoma of the Gallbladder: a case report and review of the literature

Acute cholecystitis as a rare presentation of metastatic breast carcinoma of the Gallbladder: A case report and review of the literature

 

Belhachmi Abdelilah^{1, &}, Ouazni Mohamed¹, Rajae Yamoul¹, Imane Elkhiyat², A Al Bouzidi², Sifeddine Alkandry¹, Eheirchou Abdelkader¹

 

¹Service de Chirurgie Viscérale II Hôpital Militaire d’Instruction Med V ²Service de Cytologie et Anatomie Pathologique Hôpital Militaire d’Instruction Med V

 

 

^&Corresponding author
Belhachmi Abdelilah, Service de Chirurgie Viscérale II Hôpital Militaire d’Instruction, Med V, Morocco

 

 

 

 

Breast cancer is the most frequent malignant tumours among female. At moment of diagnosis, 60% of the patients have lymph or distant organ metastases, and about 30-80 % of the patient will develop metastatic disease following surgery and/or chemotherapy, radiotherapy or hormonotherapy [1, 2]. Breast cancer is usually associated with metastases to lungs, bones and liver. Breast carcinoma metastasizing to the gallbladder is very rare. We report a case of metastatic breast cancer that was discovered incidentally during a cholecystectomy in a patient undergoing surgery for acute cholecystitis.

 

 

A 45-year-old woman presented with a 2-day history of progressively worsening abdominal pain in the right upper quadrant and vomiting, fever and headache. Three months previously, she had undergone a right radical mastectomy with axillar dissection, and pathologic examination revealed an invasive lobular carcinoma, corresponding to T3N1M0, Estrogen receptors, progesterone receptors and cerb B2 were positive. Adjuvant chemotherapy and radiotherapy were stared. To the emergency room, on physical examination, body temperature was 38. 3 c, blood pressure 125/65 mmHg, and pulse rate 105 /min. Abdominal examination revealed tenderness in the right upper abdomen and rigidity of the abdominal wall with positive murphy's sign. Laboratory testing revealed a hemoglobin level of 10. 5 g/dl, a white cell count of 15. 800/ul with 90 % neutrophils, Biochemical tests were within normal rang (SGPT, SGOT, ALP, gamma-GT, conjugated and unconjugated bilirubin, LDH, lipase). Ultrasound examination revealed a sludge and irregular thickness of the gallbladder. The diagnostic of acute cholecystitis was made. The patient underwent open laparotomy and cholecystectomy without complication. The nodule was perceptible and palpable on the gallbladder wall (Figure 1) , without gross involvement of the liver or regional lymph nodes, examination of the abdominal cavity showed no signs of peritoneal metastases. On gross examination, the Gallbladder was thickened, with a 1. 5 cm palpable mass (Figure 2, Figure 3, Figure 4). Histopathological examination, however, revealed the metastasis. The gallbladder wall was infiltrated (muscular layer and adventitia) by lobular breast carcinoma, hormone receptors were positive (Figure 5, Figure 6, Figure 7). Additionally, the pathological evaluation showed features of chronic cholecystitis with fibrosis of the Gallbladder wall.

 

 

Gallbladder is an uncommon site for metastasis. Tumours which commonly metastasize to the gallbladder are malignant melanoma and it occurs in 15 % of cases [3, 4]. Other less common primary sites leading to secondary metastasis to gallbladder include renal cell cancer, lungcancer, cervical cancer and breast cancers [5]. Breast carcinoma metastasizing to the gallbladder is extremely rare. In a large unselected autopsy series, metastases to the gallbladder were found only in 5. 8% of cancer patients [6].

Lobular cancers of the breastoften show a preference to metastasise to the gastrointestinal tract compared to ductal cancers, and very few cases of metastasis to the gallbladder were been published in the literature [7, 8]. The affinity for lobular cancers to metastasise to gastrointestinal tract is not well understood [9]. The clinical symptomatology of metastasis to the gallbladder is usually manifests with symptoms of acute/chronic cholecystitis or abdominal pain prevail [7-10]. Similarly to the reported cases symptoms of cholecystitis characterized the present case.

The differential diagnosis between primary carcinoma of the gallbladder and metastatic breast carcinoma to the gallbladder is of great importance to the management of the disease [11]. Thus, molecular biologyand immunohistochemical evaluation are often necessary.

The treatment of metastatic breast carcinoma is usually difficult, complex and sometimes aggressive, combining surgery, chemotherapy and hormonotherapy [12]. Prognosis of metastatic breast cancer is regarded as dismal and uncertain. Although resection should be considered as palliative treatment in a patient with gallbladder metastasis from breast carcinoma, it is recommended in a case which exhibits symptoms [13]. Our clinical case and review of the published cases suggests the need for careful evaluation of abdominal symptoms and strict surveillance of the gallbladder during routine imaging examination in breast cancer patients.

Although metastatic gallbladder is rare in breast cancer patients, breast cancer especially lobular type has the potential to metastasize to the gallbladder, and this diagnosis should be considered for patients with breast cancer who present with signs or symptoms of cholecystitis.

 

 

Metastatic gallbladder involvement is rare, especially in a case of primary breast carcinoma. It usually manifests with abdominal pain, mimicking acute or chronic cholecystitis. The prognosis is poor [14]. Thereby, symptoms of acute/chronic cholecystitis or right hypochondrial pain in a patient with a history of breast carcinoma should raise the suspicion of metastatic gallbladder disease that must be treated properly as it portends a poor prognosis.

 

 

The authors declare no competing interests.

 

 

All the authors have contributed to the writing of this paper and have read and approved the final version.

 

 

Figure 1: intraoperative picture showing a nodule in the gallbladder wall

Figure 2: gallbladder after resection with a nodule in the wall

Figure 3: gallbladder metastasis

Figure 4: Linear or single-cell file (‘‘Indian-file’’) pattern of infiltration is characteristic of lobular carcinoma (HEx40)

Figure 5: Invasion of the muscularis propria of the gallbladder by metastatic lobular carcinoma of the breast

Figure 6: Metastatic lobular breast carcinoma (bottom left) Infiltrating the gallbladder wall (top right) : ( HEx20)

Figure 7: Estrogen positive cells in gallbladder wall on immunohistochemical staining

 

 

1. Bamias A, Baltayiannis G, Kamina S, Fatouros M, Lymphopoulos E, Agnanti N, Tsianos E, Pavlitis N. Rectal metastases from lobular carcinoma of the breast: report of case and literature review. Annals of oncol. 2001 May;12(5) :715-8. PubMed | Google Scholar


2. Dinesh CD, Komal B, Keechelat P, Jai BS, Ashok KV, Digant H. Breast carcinoma with metastasis to the gallbladder: an unusual case report with a short review of literature. HepatobiliaryPancreat Dis Int. 2006 May;5(2) :305-7. PubMed | Google Scholar


3. Langley RG, Bailey EM, Sober AJ. Acute cholecystitis from metastatic Melanoma to the gall-bladder in a patient with a low risk melanoma. Br J Dermatol. 1997; 136(2) :279-82. PubMed | Google Scholar


4. Lee YT. Breast carcinoma: pattern of metastasis at autopsy. J SurgOncol. 1983; 23(3) :175-80. PubMed | Google Scholar


5. Shah RJ, Koehler A, Long JD. Bile peritonitis secondary to breast Cancer metastatic to the gallbladder. Am J Gastroenterol. 2000 May;95(5) :1379-81. PubMed | Google Scholar


6. Abrams HL, Spiro R, Goldstein N. Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer. 1950; 3(1) :74-85. PubMed | Google Scholar


7. Beaver BL, Denning DA, Minton JP. Metastatic breast carcinomaof the gallbladder. J SurgOncol. 1986; 31(4) :240-242. PubMed | Google Scholar


8. Calafat P, de Diller AB, Sanchez C. Breast carcinoma metastasis in ileum-colon and gallbladder simulating inflammatory diseases (Article in Spanish). Rev FacCien Med UnivNac Cordoba. 1999; 56 (2) :123-7. PubMed | Google Scholar


9. Borst MJ, Ingold JA. Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993 Oct;114(4) :637-41 - discussion 641-2. PubMed | Google Scholar


10. Murguia E, Quiroga D, Canteros G, Sanmartino C, Barreiro M, HerreraJ. Gallbladder metastases from ductal papillary carcinoma of the breast. J HepatobiliaryPancreatSurg. 2006;13 (6) :591-593. PubMed | Google Scholar


11. Lee AK, DeLellis RA, Rosen PP. Alphalactalbumin as an Immuno-histochemical marker for metastatic breast carcinomas. Am J Surg Pathol. 1984 ; 8 : 93. PubMed | Google Scholar


12. Kopelson G, Chu AM, Doucette JA, Gunderson LL. Extrahepaticbiliary tract metastases from breast cancer. Int J Radiat Oncol Biol Phys. 1980; 6 : 497. PubMed | Google Scholar


13. Manouras A, Lagoudianakis EE, Genetzakis M, Pararas N, Papadima A, Kekis PB. Metastatic breast carcinoma initiallypresenting as acute cholecystitis : a case report and review ofthe literature. Eur J GynaecolOncol. 2008; 29(2) :179-81. PubMed | Google Scholar


14. Doval CD, Bhatia K, Pavithran K, Sharma JB, Vaid AK, Hazarika D. “Breast carcinoma with metastasis to the gallbladder: an unusual case report with a short review of the literature”. HepatobiliaryPancreat Dis Int. 2006 May; 5(2) :305-7. PubMed | Google Scholar