Scleroderma and type 1 diabetes: a rare association
Nassiba Elouarradi, Nawal El Ansari
The Pan African Medical Journal. ;30:77. doi:10.11604/pamj..30.77.15720

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Scleroderma and type 1 diabetes: a rare association

Nassiba Elouarradi, Nawal El Ansari
Pan Afr Med J. 2018; 30:77. doi:10.11604/pamj.2018.30.77.15720. Published 29 May 2018

The association of type 1 diabetes and systemic scleroderma is rarely reported in the literature, the pathogenesis of this association is unknown, interferon seems to have a major role in being an immunomodulator and inhibitor of collagen production, and it is also involved in autoimmune pathology. Note that this association could be at the origin of a difficulty of passage of the insulin in the sites of injections, responsible for a major glycemic imbalance. We report the case of a 26-year-old patient, who had been diabetic for 6 years on insulin, who was referred for a glycemic imbalance, who had a clinical examination objectifying multiple morphea lesions on the roots of the thighs, arms, abdomen and thorax. A cutaneous biopsy was performed, showing a sclerodermiform appearance with significant fibrosis without sign of malignancy, result rather in favor of a scleroderma.

Corresponding author:
Nassiba Elouarradi, Service of Endocrinology, Diabetology and Metabolic Diseases, University Hospital of Marrakech, Marrakech, Morocco

©Nassiba Elouarradi et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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