Scleroderma and type 1 diabetes: a rare association
Nassiba Elouarradi, Nawal El Ansari
The Pan African Medical Journal. ;30:77. doi:10.11604/pamj..30.77.15720

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Images in clinical medicine

Scleroderma and type 1 diabetes: a rare association

Nassiba Elouarradi, Nawal El Ansari
Pan Afr Med J. 2018; 30:77. doi:10.11604/pamj.2018.30.77.15720. Published 29 May 2018



The association of type 1 diabetes and systemic scleroderma is rarely reported in the literature, the pathogenesis of this association is unknown, interferon seems to have a major role in being an immunomodulator and inhibitor of collagen production, and it is also involved in autoimmune pathology. Note that this association could be at the origin of a difficulty of passage of the insulin in the sites of injections, responsible for a major glycemic imbalance. We report the case of a 26-year-old patient, who had been diabetic for 6 years on insulin, who was referred for a glycemic imbalance, who had a clinical examination objectifying multiple morphea lesions on the roots of the thighs, arms, abdomen and thorax. A cutaneous biopsy was performed, showing a sclerodermiform appearance with significant fibrosis without sign of malignancy, result rather in favor of a scleroderma.


Corresponding author:
Nassiba Elouarradi, Service of Endocrinology, Diabetology and Metabolic Diseases, University Hospital of Marrakech, Marrakech, Morocco
nassibaelouarradi@gmail.com

©Nassiba Elouarradi et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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