Minoxidil induced hypertrichosis in children
Najwa Guerouaz, Ait Ourhroui Mohamed
The Pan African Medical Journal. ;18:8. doi:10.11604/pamj..18.8.3637

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Minoxidil induced hypertrichosis in children

Najwa Guerouaz, Ait Ourhroui Mohamed
Pan Afr Med J. 2014; 18:8. doi:10.11604/pamj.2014.18.8.3637. Published 02 May 2014

Minoxidil is a strong arterial vasodilator used in the treatment of hypertension. In dermatology, topic minoxidil is widely used to treat hair fall. Hypertrichosis may occur if this form is misused. A 5 year-old girl developed patchy alopecia areata of the scalp. She was treated by minoxidil lotion 2% 10 times a day without medical prescription. Regrow of hair was rapidly obtained. However, the parents complained of extensive hypertrichosis covering the face (A, B) and the back (C). Physical examination revealed no hypotension and hirsutism evaluated at 20/36 on the Ferriman and Gallwey scale. Serum levels of 17 hydroxyprogesterone, 17alfa progesterone, testosterone and cotisol were within normal ranges excluding hormonal disorder. Discontinuation of minoxidil was followed by progressive regression of hypertrichosis. Systemic effects are rarely reported with minoxidil lotions. Indeed, transcutaneous absorption is insignificant ranging from 0,3 to 4,5%. The main systemic side effects include hypotension, tachycardia and ECG changes. Hypertrichosis has been reported more frequently in females than in males. This side effect is dose-related and is manly localized in the face. Discontinuation of treatment makes this trouble reversible. However medical supervision must be considered for a long time because of the product's very long action. Minoxidil must be delivered on medical prescription to ensure the maximum security use especially in children and women.

Corresponding author:
Najwa Guerouaz, University hospital Ibn Sina, Department of Dermatology, Morocco

©Najwa Guerouaz et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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