A case of bilateral thalamic infarct complicating tuberculous meningoencephalitis
Jehanne Aasfara, Wafa Regragui, Loubna El Ouardi, El Hachmia Ait Ben Haddou, Ali Benomar, Mohammed Yahyaoui
The Pan African Medical Journal. 2019;33:2. doi:10.11604/pamj.2019.33.2.13327

Innovations in Measles Elimination Innovations in Measles Elimination
"Better health through knowledge sharing and information dissemination "

Case report

A case of bilateral thalamic infarct complicating tuberculous meningoencephalitis

Cite this: The Pan African Medical Journal. 2019;33:2. doi:10.11604/pamj.2019.33.2.13327

Received: 11/07/2017 - Accepted: 25/05/2018 - Published: 06/05/2019

Key words: Tuberculosis, meningoencephalitis, stroke, bithalamic, movement disorders

© Jehanne Aasfara et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.panafrican-med-journal.com/content/article/33/2/full

Corresponding author: Jehanne Aasfara, Department of Neurology and Neurogenetics, Hôpital des Spécialités ONO, CHU Rabat-Salé, Morocco (j.aasfara@gmail.com)


A case of bilateral thalamic infarct complicating tuberculous meningoencephalitis

Jehanne Aasfara1,&, Wafa Regragui1,2, Loubna El Ouardi1, El Hachmia Ait Ben Haddou1,2, Ali Benomar1,2, Mohammed Yahyaoui1,2

 

1Department of Neurology and Neurogenetics, Hôpital des Spécialités ONO, CHU Rabat-Salé, Morocco, 2Faculty of Medicine and Pharmacy, University Mohamed V Souissi, Rabat, Morocco

 

 

&Corresponding author
Jehanne Aasfara, Department of Neurology and Neurogenetics, Hôpital des Spécialités ONO, CHU Rabat-Salé, Morocco

 

 

Abstract

Ischemic stroke can result from multiple etiologies. It can also be a complication of tuberculous meningoencephalitis and determine its outcome. stroke secondary to tuberculous meningoencephalitis, occurs in 30% cases in the basal ganglia region, unusually in the thalamus. The mechanism of stroke in this condition is vasculitis. We report an unusual case of bilateral thalamic infarcts complicating tuberculous meningoencephalitis. Ischemic stroke in tuberculous meningoencephalitis is unpredictable with poor prognosis despite antituberculous drug treatment, emphasising the importance of primary prevention, particularly in tuberculosis endemic areas.

 

 

Introduction    Down

Ischemic stroke in tuberculous meningoencephalitis (TME), occurs in the basal ganglia region, internal capsule and rarely in the thalamus [1, 2]. Bilateral infarct is exceptional [3]. We report a rare case of bilateral thalamic infarcts complicating tuberculous meningoencephalitis.

 

 

Patient and observation Up    Down

A 15 year-old male, with no medical history, presented with febrile coma. Cerebral CT scan was normal and cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis (160cells/mm3), protein concentration up to 0.97g/l, glucose at 1.6mmol/l (CSF/blood glucose < 0.5) and hyponatremia in serum analysis. The patient was treated by intravenous steroids for three days and antituberculous drugs. Fifteen days later; the patient developed agitated confusion with left hemiparesis and was referred to our department for further investigation and care. Neurological examination revealed fluctuant altered consciousness, left hemiparesis, axial twisting movements on the left upper limb with severe dystonia. Brain MRI found bilateral anterior and medial thalami ischemic lesions extended to internal globus pallidus and subthalamic nucleus with hypothalamic enhancement (Figure 1 and Figure 2). CSF analysis showed 36 cells/mm3 (92% lymphocytes), protein at 1.19g/l, glucose 2mmol/l. Mycobacterium tuberculosis Culture in CSF and 3 sputum examinations were negative. Plasma Angiotensin I-converting enzyme was normal. Thoracic CT scan showed bilateral asymmetric mediastinal lymphadenopathy with hypodense centers evoking caseous necrosis. Bronchoscopy with bronchial biopsies revealed no specific bronchial mucosal inflammation. Bronchoalveolar lavage showed polynucleosis. The diagnosis of bilatreal thalamic infarct complicating TME was made. Antituberculous drugs were maintained and oral corticosteroids administered with symptomatic treatment based on trihexyphenidyle, diazepam, botulinum toxine and fluoxetine. The outcome was favorable concerning hemiparesis, mutism and movement disorders but the patient was disabled by left segmental dystonia and showed some behavioral disorders that resolved with haloperidol. Three months later, cerebral MRI showed nearly complete resolution of signal abnormalities but neuropsychological assessment revealed thalamic dementia.

 

 

Discussion Up    Down

Our patient illustrates vascular complication of tuberculous meningoencephalitis. Cerebral vasculitis is a rare cause of blood vessel walls inflammation. Stroke occurs in 15-57% of tuberculous meningitis cases [4]. The primary mechanism of stroke in tuberculous meningoencephalitis is inflammation of both large and small vessels walls [5]. "tubercular zone" supplied by medial striate and thalamo- perforating arteries, is the most frequently involved area. It includes the caudate, anterior thalamus, anterior limb and genu of the internal capsule [4-6]. Bilateral thalamic infarcts represented approximately 0.6% of all cerebral infarctions and result of Percheron artery occluision [7]. In our knowledge, bithalamic infarct has been reported in only two cases of tuberculous meningoencephalitis [8, 9]. It has been previously demonstrated that early strokes in TME are mediated by vasospasm and later strokes by proliferative intimal disease. stroke occur in our case, fifteen days after initiation of antituberculous drugs. It is likely immune-mediated reaction resulting of host-organism interaction. Indeed, vascular complications are more commonly seen in chronic meningoencephalitis and continue to develop during the first weeks of treatment (9%) [10]. In some cases, stroke can be concomitant to corticosteroid decrease which was the case of our patient. Neverthless, the preventive role of corticosteroids remains a subject of controversy [7]. Movement disorders in TME have been reported in up to 16.6% cases. Basal ganglia infarcts are presumably one of their mechanisms. There is poor correlation between neurological findings and focal lesion on imaging studies [11]. Dystonia is commonly due to frontal or parietal lesions and rarely to basal ganglia lesions [12]. In our patient, we can qualify axial twisting mouvements of hand as "thalamic hand" and dystonia of proximal left upper limb as "thalamic contracture." Thalamic contracture is induced by posterior thalamic lesions whereas they were on anterior nuclei in our patient. We can explain these mouvement disorders by extensive bilateral lesions wich disrupted basal ganglia circuit. The poor outcome of our patient is likely due to cognitive impairment and focal dystonia secondary to multiple basal ganglia infarcts wich reported to be associated with poor prognosis than single infarcts (46.7% versus 32%) [13].

 

 

Conclusion Up    Down

Ischemic stroke in tuberculous meningoencephalitis is unpredictable with poor prognosis despite early treatment, especially in multiple infarcts, suggesting the importance of primary prevention, particularly in tuberculosis endemic areas.

 

 

Competing interests Up    Down

The authors declare no competing interests.

 

 

Authors’ contributions Up    Down

Jehanne Aasfara and Wafa Regragui analyzed and interpreted the patient data. Wafa Regragui and Jehanne Aasfara were as a major contributor in writing the manuscript. All authors read and approved the final manuscript.

 

 

Figures Up    Down

Figure 1: cerebral MRI axial T2 weighted image: abnormal signal in bilateral anterior thalami and right capsular genu

Figure 2: cerebral MRI sagittal T1 weighted image: hypothalamic enhancement after contrast administration

 

 

References Up    Down

  1. Anuradha HK, Garg RK, Agarwal A, Sinha MK, Verma R, Singh MK, Shukla R. Predictors of stroke in patients of tuberculous meningitis and its effect on the outcome. Q J Med. 2010; 103(9): 671-8. Epub 2010 Jun 29. PubMed | Google Scholar

  2. Razmeh S, Habibi AH ,Ghorchian Z, Eslami M, Haeri G. Acute Stroke Secondary to Tuberculous Meningitis: a case report and review of literature. International Journal of Prevention and Treatment. 2017; 6(1): 1-3.

  3. J ennifer Linn, Danek A, Hoffmann LA, Seelos KC, Brückmann H. Differential Diagnosis of Bilateral Thalamic Lesions Clinical Neuroradiology. 2007; 17(1): 3-22. Google Scholar

  4. Misra U, Kalita J, Maurya P. Stroke in tuberculous meningitis. J Neurol Sci. 2011; 303(1-2): 22-30. Epub 2011 Jan 26. PubMed | Google Scholar

  5. Thwaites GE, Macmullen-Price J, Tran TH, Pham PM, Nguyen TD, Simmons CP, White NJ, Tran TH, Summers D, Farrar JJ. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol. 2007; 6(3): 230-6. PubMed | Google Scholar

  6. Hsieh FY1, Chia LG, Shen WC. Locations of cerebral infarctions in tuberculous meningitis. Neuroradiology. 1992; 34(3): 197-9. PubMed | Google Scholar

  7. Gossner J, Larsen J, Knauth M. Bilateral thalamic infarction: a rare manifestation of dural venous sinus thrombosis. Clin Imaging. 2010; 34(2): 134-7. PubMed | Google Scholar

  8. Shikama Y, Kuriu K, Fukui T, Kawada H, Nakajima H. Acute onset of somnolence and amnesia due to cerebral infarction of bilateral thalamus accompanied with tuberculous meningitis: a case report. Kekkaku. 2004; 79(8): 469-73. PubMed | Google Scholar

  9. Wakai M, Hayashi M, Honda K, Nishikage H, Goshima K, Yamamoto J. Acute onset of tuberculous meningoencephalitis presenting with symmetric linear lesions in the bilateral thalamus: a case report. Rinsho Shinkeigaku. 2001; 41(8): 519-22. PubMed | Google Scholar

  10. Lammie GA, Hewlett RH, Schoeman JF, Donald PR. Tuberculous cerebrovascular disease: a review. J Infect. 2009; 59(3): 156-66. Epub 2009 Jul 25. PubMed | Google Scholar

  11. Alarcón F, Giménez-Roldán S. Systemic diseases that cause movement disorders. Parkinsonism Relat Disord. 2005; 11(1): 1-18. Epub 2004 Dec 15. PubMed | Google Scholar

  12. Defebvre L, Krystkowiak P. Movement disorders in stroke. Rev Neurol (Paris). 2016; 172 (8-9): 483-487. Epub 2016 Jul 28. PubMed

  13. Springer P1, Swanevelder S, van Toorn R, van Rensburg AJ, Schoeman J. Cerebral infarction and neurodevelopmental outcome in childhood tuberculous meningitis. Eur J Paediatr Neurol. 2009; 13(4): 343-9. Epub 2008 Aug 30. PubMed | Google Scholar

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


The Pan African Medical Journal articles are archived on Pubmed Central. Access PAMJ archives on PMC here

Volume 33 (May - August 2019)

Article tools

PDF (456 Kb)
Contact the corresponding author
Download to Citation Manager
EndNote
Reference Manager
Zotero
BibTex
ProCite


Keywords

Tuberculosis
Meningoencephalitis
Stroke
Bithalamic
Movement disorders

Rate this article

Altmetric

PAMJ is a member of the Committee on Publication Ethics
PAMJ Authors services
Next abstract

PAMJ is published in collaboration with the African Field Epidemiology Network (AFENET)
Currently tracked by: DOAJ, AIM, Google Scholar, AJOL, EBSCO, Scopus, Embase, IC, HINARI, Global Health, PubMed Central, PubMed/Medline, Ulrichsweb, More to come . Member of COPE.

ISSN: 1937-8688. © 2019 - Pan African Medical Journal. All rights reserved