Prevalence of precancerous cervical lesions in women attending Mezam Polyclinic Bamenda, Cameroon
Ngwayu Claude Nkfusai, Tchakounte Minette Mubah, Brenda Mbouamba Yankam, Tabe Armstrong Tambe, Samuel Nambile Cumber
The Pan African Medical Journal. 2019;32:174. doi:10.11604/pamj.2019.32.174.16895

Innovations in Measles Elimination Innovations in Measles Elimination
"Better health through knowledge sharing and information dissemination "

Research

Prevalence of precancerous cervical lesions in women attending Mezam Polyclinic Bamenda, Cameroon

Cite this: The Pan African Medical Journal. 2019;32:174. doi:10.11604/pamj.2019.32.174.16895

Received: 21/08/2018 - Accepted: 24/02/2019 - Published: 10/04/2019

Key words: Precancerous lesion, cervix, age, screening, Mezam polyclinic

© Ngwayu Claude Nkfusai et al. The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.panafrican-med-journal.com/content/article/32/174/full

Corresponding author: Samuel Nambile Cumber, Section for Epidemiology and Social Medicine, Department of Public Health, Institute of Medicine (EPSO), The Sahlgrenska Academy at University of Gothenburg, Box 414, SE – 405 Gothenburg, Sweden (samuel.cumber@gu.se)


Prevalence of precancerous cervical lesions in women attending Mezam Polyclinic Bamenda, Cameroon

Ngwayu Claude Nkfusai1, Tchakounte Minette Mubah2, Brenda Mbouamba Yankam1, Tabe Armstrong Tambe3, Samuel Nambile Cumber3,&

 

1Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon, 2Department of Medical Laboratory Science, Faculty of Health Sciences, University of Bamenda, Bamenda, Cameroon, 3Department of Nursing, Institute of Health and Biomedical Science, Cameroon Christian University Bali, Bali, Cameroon, 4Section for Epidemiology and Social Medicine, Department of Public Health, Institute of Medicine (EPSO), The Sahlgrenska Academy at University of Gothenburg, Box 414, SE – 405 Gothenburg, Sweden

 

 

&Corresponding author
Samuel Nambile Cumber, Section for Epidemiology and Social Medicine, Department of Public Health, Institute of Medicine (EPSO), The Sahlgrenska Academy at University of Gothenburg, Box 414, SE – 405 Gothenburg, Sweden

 

 

Abstract

Introduction: precancerous cervical lesion is significantly a health problem globally. Thus, screening targeting women between the ages of 17-60 is being undertaken in developing countries, including Cameroon. Over 50% (7.8 per 100,000) women die of cervical cancer every year. This study was to determine the prevalence of precancerous cervical lesion, the age demography and access the risk factor.

 

Methods: a hospital-based cross-sectional study was conducted from August 09th to October 17th 2017. A total of 60 women participated, and were screened for precancerous cervical lesion. Data were collected by using a questionnaire. Visual inspection with acetic acid and visual inspection with Lugol’s iodine was applied for the screening. SPSS version 16.0 was used for data entry and analysis. Logistic regression analysis was fitted and odds ratios with 95% confidence intervals and p-values were computed to identify factors associated with precancerous cervical cancer lesion.

 

Results: out of 60 study participants, 2(3.33%) were found to be positive for precancerous cervical cancer lesion.

 

Conclusion: the prevalence of precancerous cervical lesion in women that consulted at the Mezam polyclinic is high.

 

 

Introduction    Down

Women in Africa as well as those residing in Cameroon, suffer a disproportionate rate of cervical cancer morbidity and mortality [1]. Cervical cancer is the second leading cause of cancer-related deaths amongst Cameroonian women in West Africa. Human papillomavirus (HPV) leads to cervical cancer. Particularly, the strains HPV 16 and 18 have been especially known to be at high risk [2]. In Cameroon, cervical cancer screening services and testing for HPV are mostly available at private health clinics and some government hospitals in the urban areas. In Cameroon most cases of cervical cancer are diagnosed at later and more serious stages. Majority of the cervical cancer victims are poor rural women who are particularly unable to access screening and testing services [2, 3]. Those who screen are unable to return for follow-up or complete treatment due to: inadequate medical advice, lack of awareness of the significance of their symptoms, cultural and religious factors as well as the lack of finances to pay for the services.

 

The cancer of the cervix is at the origin of 3 387 new cases and of 1000 deaths per annum corresponding to an average incidence of 8 per 100 000 person-years in 2000. It is located at the 2nd rank of female cancers in term of incidence and there thus remains a priority to public health [4]. In Cameroon one estimates that approximately 1400 to 1700 new cases of cancer of the cervix per annum and approximately 700 of them die each year [5]. The cancer of the cervix is preceded during 10 to 15 years by precancerous lesions. Those are detectable by the smear and their treatment makes it possible to avoid or reduce the risk of evolution towards an invasive cancer [6]. The screening of the cancer of the cervix in Europe (France) is individual but there are recommendations for clinical practice where it is advised to carry out a smear every 3 years after 2 normal annual smears for women from 25 to 65 years [7].

 

A precancerous state of the cervix is characterized by changes undergone by the cells of the collar which make them more likely to evolve in a cancer. This state is not yet a cancer, but it is strongly likely to be transformed into cancer of the cervix in 10 years or more if it is not treated in time [8]. One finds a cervical dysplasia at 1 to 5% of the women in the general population. They concern primarily the young, old women from 25 to 35 years [9]. It is estimated that each year, appear approximately 69 000 new cases of dysplasia of low rank and 15 000 cases of dysplasia of high rank in Europe [10]. The papillomavirus (human papillomavirus: HPV) are known and are very many, they are responsible for a multitude of lesions found on the skin or the mucous membranes [11]. By infecting the cells of the cervix, they lead to lesions which at term can evolve to a cancer. The co-infection by viruses AIDS and HPV is at the origin of a growing number of cancers for seropositive people. A new study on nearly a half-million patients shows it with force [12].

 

Five main types of cancer that affect a woman's reproductive organs are known as gynecologic cancer: cervical, ovarian, uterine, vaginal, and vulvar (Centers for Disease Control and Prevention) [13]. According to [14], of the 83,745 women diagnosed with gynecologic cancer in the United States died from the disease. CDC further stated that cervical cancer used to be the leading cause of cancer death for women in the United States. However, in the past 40 years, the number of cases of cervical cancer and the number of deaths from cervical cancer have decreased significantly because of the availability of regular Pap tests, which can locate cervical precancerous lesions before they turn into cancer. Mqoqi et al. and Bailie RS et al. [14, 15] said cervical cancer can be prevented using: the HPV vaccines, the Pap test (or Pap smear) looking for pre-cancers, and also using Visual inspection with acetic acid (VIA), Visual inspection with Lugol’s iodine (VILI), the HPV test that looks for viruses that can cause cellular changes. Regular screening beginning at the age of 17 is the most important preventive measure. Other preventive measures include: the use of condoms during sexual contacts, limiting the number of sexual partners and avoid smoking [15].

 

Atypical squamous cells: if the doctor tells a woman that she has atypical squamous cells, it means that abnormalities has been detected in the squamous cells of her cervix. This can indicate that she has a human papillomavirus (HPV) infection, another infection, or possibly precancerous cells of another cause. The doctor may recommend further testing to determine what the abnormalities are. In some cases, this may simply mean a repeat Pap test in a few months. A test with this kind of finding may be reported as “atypical squamous cells of uncertain significance,” abbreviated as ASCUS (Figure 1).

 

Squamous intraepithelial lesion (SIL): this lesion means that you have changes on your cervix that may be precancerous. SIL lesions are classified as either low-grade (LSIL) or high-grade (HSIL), with high-grade lesions being more likely to progress to cervical cancer (Figure 2). Transformation zone (TZ) is the name given to the area of the cervix comprising epithelium that has undergone squamous metaplastic change. It is the area of squamous metaplasia between the squamocolumnar junction and the ectocervix. It is characterized by immature squamous epithelium beneath which endocervical crypts may be seen on histology. This area is where most abnormalities are thought to arise (Figure 3, Figure 4). Three vaccines Gardasil, Gardasil-9, and Cervarix have been approved by the food and drug administration (FDA) to help prevent infection with some types of HPV, including the types that cause most cases of cervical cancer. Gynecologists suggest that, boys and girls both should be vaccinated between ages 11 and 12 before they become sexually active; those between ages 13 and 26 who have not yet received the vaccine should also be vaccinated.

 

 

Methods Up    Down

Study area, design and population

 

The study was carried out at Mezam polyclinic since they have the necessary facilities and the women who come are sure to be tested for and treated if need be. The study was a hospital based cross-sectional survey. The study included all women who signed the inform consent form.

 

Sample size

 

The sample size was calculated based on the LORENTZ formula

 

Calculated sample size r n = t × t × p (1 - p)/ m × n

 

When n = required sample size t = confidence level at 95 % (standard value 1.96); m = margin of error 5% (standard value of 0.05); p = prevalence estimated of a condition under investigation in the project (3.9% of women where tested positive for precancerous cervical lesions (39).

 

t = 1.96, m = 0.05, p = 3.9 %( 0.1)

 

n = 1.96 × 1.96 × 0.039(1-0.039)/0.05×0.05

 

n = 3.8426 × 0.037/0.0025

 

n = 3.8416 × 14.8

 

n = 56.9.

 

Sampling: a total of 60 (due to time constrains) women were recruited for the study, using the random sampling method.

 

Selection criteria

 

Inclusive criteria: only sexual active women of ages 17-60 will participate in the study. This is because this infection occurs most often in women within this age group.

 

Exclusive criteria: non-sexual active women within the said age range shall not take part in the study. This is because there is a lesser chance for non-sexual active women to come down with precancerous cervical lesions. Women who did not sign the consent form were excluded from the research work.

 

Materials: examination table, adequate light source, sterile vaginal speculum, new examination gloves, large cotton swabs, dilute (3-5%) acetic acid (vinegar) and a small bowl, lugol’s iodine solution and a small bowl, a plastic bucket with a plastic bag.

 

Test procedure

 

Visual inspection with 5% acetic acid (VIA)

 

The woman is asked to lie in a gynecological position, and the external genitalia os examined with the help of a good light source. A speculum is used to help open the vagina and expose the external os of the cervix. A large cotton swab is deep in the bowl containing 5% acetic acid is applied to the external os. After a minute, view the cervix with the naked eyes to identify color changes on the cervix. To determine whether the test result is positive (Abnormal tissue temporarily appears white when exposed to acetic acid) or negative (no color change) for possible precancerous lesions or cancer (Figure 5). If the result is positive a confirmatory test is done using Lugol’s iodine. A large cotton swab is deep in a bowl containing Lugol’s iodine and it’s applied to the cervix. After a minute, visually observe the cervix for positive (mustard-yellow coloration) or negative (brown coloration) (Figure 6, Figure 7). Demographic and clinical data were collected using questionnaire and information from the participants was presented on tables. Data was analysed using Microsoft excel (2010) by calculating the prevalence. A record book was used to record all information about participants and later transferred and statistical calculations done.

 

Ethical consideration: an ethical approval was obtained from the institutional board of the Faculty of Health Sciences, University of Buea. An authorization was obtained from the Director of the Mezam Polyclinic and the North West Delegation of Public Health. An informed consent was signed by all participants willing to take part in the study.

 

 

Results Up    Down

Out of the 60 participants, two were screened positive for precancerous cervical lesion, and 58 were screened negative. The age range was 17-60 years with a mean age of 38.5 years.

 

Demographic distribution of participants

 

Marital status: of the 60 women who participated in the study, 18 (30.00%) were singles, 29 (48.33%) were married, 5 (8.33%) were divorce and 8 (13.33%) were widows (Table 1).

 

Age distribution: out of the 60 women who enrolled, 17(28.33%) were between the age group 17-26 years, 17(28.33%) between the age groups 27-36 years, 18(30%) between 37-46 years, 6(10%) between 47-56 years, and 4 (3.33%) between 57-60 years (Table 1).

 

Evaluation of risk factors: of the 60 participants, two were screened positive within the age group of 31-45 years of age. And there were fell in the group with more than two life partners, more than 3 children, early full term pregnancy between the ages 17-20 years. One of them had a family history of cervical cancer (Table 2).

 

Prevalence of precancerous cervical lesion in women: out of the 60 women who enrolled, 2(3.33%) where screened positive for precancerous cervical lesion and 58(96.67%) were screened negative (Table 3).

 

 

Discussion Up    Down

The prevalence of precancerous lesion of the uterine cervix in Cameroon is similar to that reported in 1992 (4.2%) [16]. However, data from other countries reported a higher prevalence rate such as 16.4% women in Central African Republic Africa. In the present study, patients were not tested for HIV. In developed countries as France, the prevalence of precancerous cervical lesion rate is much lower at around of 0.5%. The difference of prevalence of the precancerous lesions of the uterine cervix from one country to another is mainly due to the existence and consistency of screening programs and management options implemented in these countries. Higher prevalence of precancerous cervical lesions in women shown by this study has been reported in South Africa (66.3%), Uganda (73%), and Zambia (76%) [17]. Studies done in Kenya and Rwanda also found the prevalence of precancerous cervical cancer to be 26.7% and 24.3% respectively, which are very high as comparable to the result of the current study. A lower prevalence of precancerous cervical cancer than the current study has also been reported from studies done in Botswana, Côte d'Ivoire, and Nigeria. In Botswana, a cervical cancer screening program of 2,175 women based on VIA found that the proportion of precancerous cervical cancer lesion confirmed by histology was 15.2% [18]. Studies recently conducted in Côte d'Ivoire and Nigeria found the prevalence of precancerous cervical cancer lesion to be 11% and 6% respectively [19]. Cervical cancer is the most common cancer in women in Africa and second to breast cancer. In Africa, it accounts for 22.2% of all cancers in women and it is also the most common cause of cancer-related death among women [20]. Knowing the prevalence and associated factors of precancerous cervical cancer lesion in women helps to take preventive measures and to know the screening requirements. In this study the prevalence of precancerous cervical cancer lesion in women was found to be 3.33% which is comparable with a previous report of Cameroon women resident in Maryland (3.9%) [21]. The high prevalence of precancerous cervical cancer lesion reveals that cervical cancer is a significant public health problem in women. Despite the high prevalence of the lesion, only four hospitals in the northwest of Cameroon were providing screening and treatment service, which significantly hampered the service accessibility to all women in the region. This could be because of the limited resources available for treatment of positive precancerous cervical cancer lesion after screening with VIA and VILI as the current limited available services are donor dependent [22].

 

The differences among findings of prevalence of precancerous cervical lesion in different regions of Africa could be partly due to differences in the sexual practices of the women studied [23]. Having multiple sexual partners because of cultural differences increases the risk of acquiring HPV, and in turn, the development of cervical pre-cancer and cancer. In Nigeria, with a low prevalence was reported, 96% of the study participants had two or less lifetime sexual partners. In South Africa, one of the highest reported, the median number of sexual partners was four [24]. In the present study the mean number of lifetime sexual partner is 3 and might be one of the contributing factors for the high prevalence. Unlike the findings from South Africa and Nigeria [25], though 56% of women had an average of five lifetime sexual partners, prevalence was lower than the finding in the present study, making the association unlikely. It could also be a result of the limitation of self-reported sexual practices. The other possible explanation for the different prevalences could be the differences in the study populations. The age ranged from 17 to 60 years with a mean age of 38.50 years and 85% of women were between the ages of 17-46 years. The mean number of deliveries for women with precancerous lesions of the uterine cervix was three childbirths and those with more than 3 deliveries represented 50%. Multiparity in women with precancerous cervical lesion was previously seen in Burkina Faso, West Africa [26]. These data lead to suggest the possibility of an association between multiple childbirths and cervical premalignant lesions in Cameroon.

 

 

Conclusion Up    Down

Much of the precancerous cervical lesion problem can be solved with existing or soon-to-be available technology, sufficient will, and modest resources. Early detection, screening, and treatment of precancerous cervical lesion as well as HPV will reduce the rate of cancer. Implementation of cervical cancer screening in all eligible Cameroon women should be a national priority. The prevalence of cervical lesion infection (3.33%) is high at the Mezam polyclinic Bamenda. The prevalence of women who are at risk of precancerous cervical lesion is within the age group of 31-45 years. The risk factors that play a role at mediating the disease are; age, more than one lifetime sexual partner, having more than three children as well as early full term pregnancy between the age of 17-20.

What is known about this topic

  • Prevalence of precancerous lesions of the uterine cervix in Cameroon;
  • Interactive model of client health behavior and cervical cancer screening of African-American women;
  • Knowledge and awareness about cervical cancer, and its prevention among interns and nursing staff in tertiary care hospitals.

What this study adds

  • The need to create awareness on the disease by sensitizing the population and screening for the disease and screening for the disease should be added as one of the screening test done during booking at antenatal;
  • More health personnel’s should be trained so that they can make available the use of VIA and VILI test for screening in the district hospitals;
  • The prevalence of precancerous lesions in Mezam Polyclinic, Cameroon.

 

 

Competing interests Up    Down

The authors declare no competing interests.

 

 

Authors’ contributions Up    Down

NCN TMM, TAT, BMY and SNC designed the study and were involved in all aspects of the study. SNC contributed to scientifically reviewing the manuscript for intellectual inputs and review. All authors reviewed the final manuscript and agreed for submission.

 

 

Acknowledgments Up    Down

We are grateful to all the women who participated in this research.

 

 

Tables and figures Up    Down

Table 1: distribution of participants based on marital status and age demographic distribution based on age groups of participants

Table 2: distribution of participants based on risks factors

Table 3: prevalence based on precancerous cervical lesion

Figure 1: an HPV infected cervix

Figure 2: precancerous cervical cancer infection of the cervix

Figure 3: normal cells of the cervix

Figure 4: a transverse section of the cervix

Figure 5: A) an acetowhite area is not significant; B) acetowhite area is significant

Figure 6: A) the squamous epithelium turns brown and columnar; B) there are scattered and uptake areas associated with immature no iodine uptake or inflammation: epithelium does not change color

Figure 7: A) well-defined, bright yellow iodine non uptake areas touching the squamo-columnar junction (SCJ); B) well-defined, bright yellow iodine non uptake areas close to uptake areas touching the squamo-columnar junction (SCJ)

 

 

References Up    Down

  1. Ackerson K. Interactive model of client health behavior and cervical cancer screening of African-American women. Public Health Nurs. 2011 May-Jun;28(3):271-80. PubMed | Google Scholar

  2. Adjorlolo-Johnson G, Unger ER, Boni-Ouattara E, Touré-Coulibaly K, Maurice C, Vernon SD, Sissoko M, Greenberg AE, Wiktor SZ, Chorba TL. Assessing the relationship between HIV infection and cervical cancer in Cote d'Ivoire: a case-control study. BMC Infect Dis. 2010 Aug 17;10:242. PubMed | Google Scholar

  3. Nji AN. Perceptions of Cameroonian Women Regarding Cervical Cancer Prevention. 2016. Google Scholar

  4. Allen JD, de Jesus M, Mars D, Tom L, Cloutier L, Shelton RC. Decision-making about the HPV vaccine among ethnically diverse parents: implications for health communications. J Oncol. 2012;2012:401979. PubMed | Google Scholar

  5. Ali SF, Ayub S, Manzoor NF, Azim S, Afif M, Akhtar N, Jafery WA, Tahir I, Farid-ul-Hasnian S, Uddin N. Knowledge and awareness about cervical cancer and its prevention amongst interns and nursing staff in Tertiary Care Hospitals in Karachi, Pakistan. PloS one. 2010 Jun 10;5(6): e11059. PubMed | Google Scholar

  6. Aragones A, Bruno D, Gany F. Attitudes surrounding implementation of the HPV vaccine for males among primary care providers serving large minority populations. J Health Care Poor Underserved. 2013 May;24(2):768-76. PubMed | Google Scholar

  7. Atashili J, Smith JS, Adimora AA, Eron J, Miller WC, Myers E. Potential impact of antiretroviral therapy and screening on cervical cancer mortality in HIV-positive women in sub-Saharan Africa: a simulation. PLoS One. 2011 Apr 4;6(4):e18527. PubMed | Google Scholar

  8. Atashili J, Miller WC, Smith JS, Ndumbe PM, Ikomey GM, Eron J, Rinas AC, Myers E, Adimora AA. Age trends in the prevalence of cervical squamous intraepithelial lesions among HIV-positive women in Cameroon: a cross-sectional study. BMC research notes. 2012 Dec;5(1):590. PubMed | Google Scholar

  9. Trim K, Nagji N, Elit L, Roy K. Parental knowledge, attitudes, and behaviours towards human papillomavirus vaccination for their children: a systematic review from 2001 to 2011. Obstet Gynecol Int. 2012;2012:921236. PubMed | Google Scholar

  10. Enow Orack GE, Ndom P, Doh AS. Cancer Incidence in Cameroon. Yaoundé Cancer registry. Programme for Appropriate Technology in Health. Planning Appropriate. 2008.

  11. Sankaranarayanan R, Budukh AM, Rajkumar R. Effective screening programmes for cervical cancer in low-and middle-income developing countries. Bull World Health Organ. 2001;79(10):954-62. Epub 2001 Nov 1. PubMed | Google Scholar

  12. Sankaranarayanan R, Black RJ, Swaminathan R, Parkin DM. An overview of cancer survival in developing countries. IARC scientific publications. 1998 Jan 1; 135-57. PubMed | Google Scholar

  13. Denny L. An evaluation of alternative strategies for the prevention of cervical cancer in low-resource settings (Doctoral dissertation, University of Cape Town). 2000. Google Scholar

  14. Mqoqi N, Kellet P, Madhoo J, Sitas F. Incidence of histologically diagnosed cancer in South Africa, 1996-1997. 2003.

  15. Bailie RS, Selvey CE, Bourne D, Bradshaw D. Trends in cervical cancer mortality in South Africa. Int J Epidemiol. 1996 Jun;25(3):488-93. PubMed | Google Scholar

  16. Gordon GMC. Carcinoma of the Cervix: A crying need for extensive screening. Hospital. 9; 36-40. Cited in Fonn et al (2003). Centre for Health Policy. 2001.

  17. Kjaer SK, Van den Brule AJ, Paull G, Svare EI, Sherman ME, Thomsen BL, Suntum M, Bock JE, Poll PA, Meijer CJ. Type specific persistence of high risk human papillomavirus (HPV) as indicator of high grade cervical squamous intraepithelial lesions in young women: population based prospective follow up study. BMJ. 2002 Sep 14;325(7364):572. PubMed | Google Scholar

  18. Koutsky LA, Ault KA, Wheeler CM, Brown DR, Barr E, Alvarez FB, Chiacchierini LM, Jansen KU. A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med. 2002 Nov 21;347(21):1645-51. PubMed | Google Scholar

  19. Tebeu PM, Petignat P, Mhawech-Fauceglia P. Gynecological malignancies in Maroua, Cameroon. International Journal of Gynecology & Obstetrics. 2009 Feb 1;104(2):148-9. PubMed | Google Scholar

  20. Jemal A, Ward E, Thun M. Declining death rates reflect progress against cancer. PLoS One. 2010 Mar 9;5(3):e9584. PubMed | Google Scholar

  21. Kouam AD. The management of pre-invasive cervical lesions using cryotherapy in Yaounde, Cameroon. J Obstet Gynaecol. 1999 Nov;19(6):640-2. PubMed | Google Scholar

  22. Soudre B, Lamien TO, Sanou M, Sankande BL. Cervical premalignant lesions of the uterine cervix in Burkina; cytologic study in two Provinces (Oudalan, Seno). Med Afr Noire. 2002; 39:806-900.

  23. Solve B, Lamien TO, Kone B, M Sanou, Sankande BL. The precancerous cervical cancer of the uterine cervix uterine collar in Burkina, to study cytological actual Alisa in two provinces (Oudalan SÃ © no). Med Af N. 1992.

  24. WHO Cancer screening Cervical Uterine © rus. In: WHO editor. The fight against cancer of the cervix Uterine © rus. Guide to essential practice. 2016; p. 83-133. PubMed | Google Scholar

  25. Robyr R, Nazeer S, Vassilakos P, Matute JC, Sando Z, Halle G, Mbakop A, Campana A. Feasibility of cytology-based cervical cancer screening in rural Cameroon. Acta Cytol. 2002 Nov-Dec;46(6):1110-6. PubMed | Google Scholar

  26. Tebeu PM, Nkele N, Fokoua S, Sandjong DI, Achu P. Prevalence of precancerous lesions of the uterine cervix in Cameroon In Bali (North West). Cameroon Journal of Medicine. 2002;11:32.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


The Pan African Medical Journal articles are archived on Pubmed Central. Access PAMJ archives on PMC here

Volume 33 (May - August 2019)

Article tools

PDF (568 Kb)
Contact the corresponding author
Download to Citation Manager
EndNote
Reference Manager
Zotero
BibTex
ProCite


Keywords

Precancerous lesion
Cervix
Age
Screening
Mezam polyclinic

Rate this article

Altmetric

PAMJ is a member of the Committee on Publication Ethics
PAMJ Authors services
Next abstract

PAMJ is published in collaboration with the African Field Epidemiology Network (AFENET)
Currently tracked by: DOAJ, AIM, Google Scholar, AJOL, EBSCO, Scopus, Embase, IC, HINARI, Global Health, PubMed Central, PubMed/Medline, Ulrichsweb, More to come . Member of COPE.

ISSN: 1937-8688. © 2019 - Pan African Medical Journal. All rights reserved