References
- Waart Anniek Van Der, Hobo Willemijin, Dolstra Harry. Time to Akt Superior tumor-reactive T cells for adoptive immunotherapy. Oncoimmunology. 2015; 4(5): e1003016-1-e1003016-3. PubMed | Google Scholar
- Klebanoff Christopher, Scott Christopher, Leonardi Anthony, Yamamoto Tori, Cruz Anthony, Ouyang Claudia et al. Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy. J Clin Invet. 2016; 126(1): 318-334. PubMed | Google Scholar
- Klebanoff Christopher, Gattinono Luca, Restifo Nicholas. Sorting through subsets: which T cell populations mediate highly effective adoptive immunotherapy. J Immunother. 2012; 35(9): 651-660. PubMed | Google Scholar
- Lamers Cor, Steenbergen-langeveld Sabine Van, Brakel Mandy Van, Ruijven Corien Grout Van, Elzakker Pascal Van, Krimpen Brigitte Van et al. T Cell Receptor-Engineered T Cells to Treat Solid Tumors: T Cell Processing Toward Optimal T Cell Fitness. Hum Gene Ther Methods. 2014; 25(6): 345-357. PubMed | Google Scholar
- Zhang Yi, Joe Gerard, Hexner Elizabeth, Zhu Jiang, Emerson Stephen. Host-reactive CD8+ memory stem cells in graft-versus-host disease. Nat Med. 2005; 11(12): 1299-1305. PubMed | Google Scholar
- Gattinoni Luca, Zhong Xiao-song, Palmer Douglas, Ji Yun, Hinrichs Christian, Yu Zhiya et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med. 2009; 15(7): 808-813. PubMed | Google Scholar
- Lugli Enrico, Dominguez Maria, Gattinoni Luca, Chattopadhyay Pratip, Bolton Diane, Song Kaimei et al. Superior T memory stem cell persistence supports long-lived T cell memory. J Clin Invet. 2013; 123(2): 594-599. PubMed | Google Scholar
- Gattinoni Luca, Klebanoff Christopher, Restifo Nicholas. Paths to stemness: building the ultimate antitumour T cell. Nat Rev Cancer. 2012; 12(10): 671-684. PubMed | Google Scholar
- Gattinoni Luca, Lugli Enrico, Ji Yun, Pos Zoltan, Paulos Chrystal, Quigley Maire et al. A human memory T cell subset with stem cell-like properties. Nat Med. 2011; 17(10): 1290-1298. PubMed | Google Scholar
- Gattinoni Luca, Restifo Nicholas. Moving T memory stem cells to the clinic. Blood. 2013 Jan 24; 121(4): 567-8. PubMed | Google Scholar
- Flynn Jacqueline, Gorry Paul. Stem memory T cells (TSCM )-their role in cancer and HIV immunotherapies. Clin Transl Immunol. 2014; 3(7): e20-e27. PubMed | Google Scholar
- Flynn Jacqueline, Gorry Paul. T cell therapies-are T memory stem cells the answer. Ann Transl Med. 2015; 3(17): 251-255. PubMed | Google Scholar
- Boudousquié Caroline, Danilo Maxime, Pousse Lourene, Jeevan-raj Beena, Angelov Georgi, Zehn Dietmar et al. Differences in the transduction of canonical wnt signals demarcate effector and memory CD8 T Cells with distinct recall proliferation capacity. J Immunol. 2014 Sep 15; 193(6): 2784-91. PubMed | Google Scholar
- Kim Eui Ho, Sullivan Jeremy, Plisch Erin, Tejera Melba Marie, Jatzek Anna, Choi Yong Kwan et al. Signal Integration by Akt Regulates CD8 TCell effector and memory differentiation. J Immunol. 2012; 188(9): 4305-4314. PubMed | Google Scholar
- Hand Timothy, Cui Weiguo, Woo Yong, Se Esen, Joshi Nickil, Chandele Anmol et al. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. PNAS. 2010; 107(38): 1-6. PubMed | Google Scholar
- Waart Anniek Van Der, Weem Noortje Van De, Maas Frans, Kramer Cynthia, Kester Michel, Falkenburg Frederik et al. Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy. Blood. 2014; 124(23): 3490-3500. PubMed | Google Scholar
- Araki Koichi, Turner Alexandra, Shaffer Virginia Oliver, Gangappa Shivaprakash, Keller Susanne, Bachmann Martin, Larsen Christian, Ahmed Rafi. mTOR regulates memory CD8 T cell differentiation. Nature. 2009; 460(7251): 108-112. PubMed | Google Scholar
- Chi Hongbo. Regulation and function of mTOR signalling in T cell fate decision. Nat Rev Immunol. 2012; 12(5): 325-338. PubMed | Google Scholar
- Rao Rajesh, Li Qingsheng, Odunsi Kunle, Shrikant Protul. The mTOR kinase determines effector versus memory CD8+ T Cell Fate by regulating the expression of transcription Factors T-bet and Eomesodermin. Immunity. 2010 Jan 29; 32(1): 67-78. PubMed | Google Scholar
- Bitto Alessandro, Ito Takashi, Pineda Victor, Letexier Nicolas, Huang Heather, Sutlief Elissa et al. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife. 2016 Aug 23; 5. pii: e16351. PubMed | Google Scholar
- Butler Marcus, Lee Jeng-Shin, Ansen Sascha, Neuberg Donna, Hodi Stephen, Murray Andrew et al. Long-Lived Antitumor CD8+ Lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell. Clin Cancer Res. 2007; 13(6): 1857-1867. PubMed | Google Scholar
- Cieri Nicoletta, Camisa Barbara, Cocchiarella Fabienne, Forcato Mattia, Oliveira Giacomo, Provasi Elena et al. IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood. 2013; 121(4): 573-584. PubMed | Google Scholar
- Crompton Joseph, Sukumar Madhusudhanan, Restifo Nicholas. Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy. Immunol Rev. 2014; 257(1): 264-276. PubMed | Google Scholar
- Weng Xiufang, Zhong Maohua, Liang Zhihui, Lu Shenjun, Hao Juan, Chen Xueling et al. Peptide-dependent inhibition of alloreactive T-cell response by soluble divalent HLA-A2/IgG molecule in vitro. transplantation. 2007; 84(10): 1298-1306. PubMed | Google Scholar
- McCoy J Philip. Handling, storage and preparation of human blood cells. Curr Prot Cytom. 1998; 5(5.1): 1-13. PubMed | Google Scholar
- Johnson Simon, Nguyen Vy, Coder David. Assessment of Cell Viability. Curr Protoc Cytom. 2013; Chapter 9: Unit9.2. PubMed | Google
Scholar
- Coder David. Assessment of cell viability. Curr Prot Cytom. 2001; 15(9.2): 1-14. PubMed | Google Scholar
- Butterfield Lisa, Koh Andrew, Meng Wilson, Vollmer Charles, Ribas Antoni, Dissette Vivian et al. Generation of human T-cell responses to an HLA-A2, 1-restricted peptide epitope derived from a-fetoprotein. Cancer Res. 1999 Jul 1; 59(13): 3134-42. Google Scholar
- Butterfield Lisa, Meng Wilson, Koh Andrew, Vollmer Charles, Ribas Antoni, Dissette Vivian et al. T Cell Responses to HLA-A*0201-Restricted peptides derived from human alpha fetoprotein. J Immunol. 2001 Apr 15; 166(8): 5300-8. PubMed | Google Scholar
- Pearce Erika. Metabolism in T cell activation and differentiation. Curr Opin Immunol. 2010; 22(3): 314-320. PubMed | Google Scholar
- Pearce Erika, Walsh Matthew, Cejas Pedro, Harms Gretchen, Shen Hao, Wang San et al. Enhancing CD8 T Cell Memory by Modulating Fatty Acid Metabolism. Nature. 2009; 460(7251): 103-107. PubMed | Google Scholar
- Benjamin Don, Colombi Marco, Moroni Christoph, Hall Michael. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov. 2011; 10(November): 868-880. PubMed | Google Scholar
- Araki Koichi, Youngblood Ben, Ahmed Rafi. The role of mTOR in memory CD8+ T-cell differentiation. Immunol Rev. 2010; 235(1): 234-243. PubMed | Google Scholar
- Huang Jian, Nguyen-McCarty Michelle, Hexner Elizabeth, Danet-Desnoyers Gwen, Klein Peter. Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR Pathways. Nat Med. 2012; 18(12): 1778-1785. PubMed | Google Scholar
- Zheng Yan, Collins Samuel, Lutz Michael, Allen Amy, Kole Thomas, Zarek Paul et al. A role for mammalian target of rapamycin in regulating T Cell activation versus anergy. J Immunol. 2007; 178: 2163-2170. PubMed | Google Scholar
- Zheng Yan, Delgoffe Greg, Meyer Christian, Chan Waipan, Powell Jonathan. Anergic T Cells are metabolically anergic. J Immunol. 2009; 183(10): 6095-6101. PubMed | Google Scholar
- Yi John, Ingram Jennifer, Zajac Allan. IL-21-deficiency Influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol. 2010; 185(8): 4835-4845. PubMed | Google Scholar
- Fröhlich Anja, Kisielow Jan, Schmitz Iwana, Freigang Stefan, Shamshiev Abdijapar, Weber Jacqueline et al. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science. 2009; 324: 1576-1580. PubMed | Google Scholar
- Elsaesser Heidi, Sauer Karsten, Brooks David. IL-21 is required to control chronic viral infection. Science. 2009; 324(5934): 1569-1572. PubMed | Google Scholar