References

  1. Waart Anniek Van Der, Hobo Willemijin, Dolstra Harry. Time to Akt Superior tumor-reactive T cells for adoptive immunotherapy. Oncoimmunology. 2015; 4(5): e1003016-1-e1003016-3. PubMed | Google Scholar

  2. Klebanoff Christopher, Scott Christopher, Leonardi Anthony, Yamamoto Tori, Cruz Anthony, Ouyang Claudia et al. Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy. J Clin Invet. 2016; 126(1): 318-334. PubMed | Google Scholar

  3. Klebanoff Christopher, Gattinono Luca, Restifo Nicholas. Sorting through subsets: which T cell populations mediate highly effective adoptive immunotherapy. J Immunother. 2012; 35(9): 651-660. PubMed | Google Scholar

  4. Lamers Cor, Steenbergen-langeveld Sabine Van, Brakel Mandy Van, Ruijven Corien Grout Van, Elzakker Pascal Van, Krimpen Brigitte Van et al. T Cell Receptor-Engineered T Cells to Treat Solid Tumors: T Cell Processing Toward Optimal T Cell Fitness. Hum Gene Ther Methods. 2014; 25(6): 345-357. PubMed | Google Scholar

  5. Zhang Yi, Joe Gerard, Hexner Elizabeth, Zhu Jiang, Emerson Stephen. Host-reactive CD8+ memory stem cells in graft-versus-host disease. Nat Med. 2005; 11(12): 1299-1305. PubMed | Google Scholar

  6. Gattinoni Luca, Zhong Xiao-song, Palmer Douglas, Ji Yun, Hinrichs Christian, Yu Zhiya et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med. 2009; 15(7): 808-813. PubMed | Google Scholar

  7. Lugli Enrico, Dominguez Maria, Gattinoni Luca, Chattopadhyay Pratip, Bolton Diane, Song Kaimei et al. Superior T memory stem cell persistence supports long-lived T cell memory. J Clin Invet. 2013; 123(2): 594-599. PubMed | Google Scholar

  8. Gattinoni Luca, Klebanoff Christopher, Restifo Nicholas. Paths to stemness: building the ultimate antitumour T cell. Nat Rev Cancer. 2012; 12(10): 671-684. PubMed | Google Scholar

  9. Gattinoni Luca, Lugli Enrico, Ji Yun, Pos Zoltan, Paulos Chrystal, Quigley Maire et al. A human memory T cell subset with stem cell-like properties. Nat Med. 2011; 17(10): 1290-1298. PubMed | Google Scholar

  10. Gattinoni Luca, Restifo Nicholas. Moving T memory stem cells to the clinic. Blood. 2013 Jan 24; 121(4): 567-8. PubMed | Google Scholar

  11. Flynn Jacqueline, Gorry Paul. Stem memory T cells (TSCM )-their role in cancer and HIV immunotherapies. Clin Transl Immunol. 2014; 3(7): e20-e27. PubMed | Google Scholar

  12. Flynn Jacqueline, Gorry Paul. T cell therapies-are T memory stem cells the answer. Ann Transl Med. 2015; 3(17): 251-255. PubMed | Google Scholar

  13. Boudousquié Caroline, Danilo Maxime, Pousse Lourene, Jeevan-raj Beena, Angelov Georgi, Zehn Dietmar et al. Differences in the transduction of canonical wnt signals demarcate effector and memory CD8 T Cells with distinct recall proliferation capacity. J Immunol. 2014 Sep 15; 193(6): 2784-91. PubMed | Google Scholar

  14. Kim Eui Ho, Sullivan Jeremy, Plisch Erin, Tejera Melba Marie, Jatzek Anna, Choi Yong Kwan et al. Signal Integration by Akt Regulates CD8 TCell effector and memory differentiation. J Immunol. 2012; 188(9): 4305-4314. PubMed | Google Scholar

  15. Hand Timothy, Cui Weiguo, Woo Yong, Se Esen, Joshi Nickil, Chandele Anmol et al. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. PNAS. 2010; 107(38): 1-6. PubMed | Google Scholar

  16. Waart Anniek Van Der, Weem Noortje Van De, Maas Frans, Kramer Cynthia, Kester Michel, Falkenburg Frederik et al. Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy. Blood. 2014; 124(23): 3490-3500. PubMed | Google Scholar

  17. Araki Koichi, Turner Alexandra, Shaffer Virginia Oliver, Gangappa Shivaprakash, Keller Susanne, Bachmann Martin, Larsen Christian, Ahmed Rafi. mTOR regulates memory CD8 T cell differentiation. Nature. 2009; 460(7251): 108-112. PubMed | Google Scholar

  18. Chi Hongbo. Regulation and function of mTOR signalling in T cell fate decision. Nat Rev Immunol. 2012; 12(5): 325-338. PubMed | Google Scholar

  19. Rao Rajesh, Li Qingsheng, Odunsi Kunle, Shrikant Protul. The mTOR kinase determines effector versus memory CD8+ T Cell Fate by regulating the expression of transcription Factors T-bet and Eomesodermin. Immunity. 2010 Jan 29; 32(1): 67-78. PubMed | Google Scholar

  20. Bitto Alessandro, Ito Takashi, Pineda Victor, Letexier Nicolas, Huang Heather, Sutlief Elissa et al. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife. 2016 Aug 23; 5. pii: e16351. PubMed | Google Scholar

  21. Butler Marcus, Lee Jeng-Shin, Ansen Sascha, Neuberg Donna, Hodi Stephen, Murray Andrew et al. Long-Lived Antitumor CD8+ Lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell. Clin Cancer Res. 2007; 13(6): 1857-1867. PubMed | Google Scholar

  22. Cieri Nicoletta, Camisa Barbara, Cocchiarella Fabienne, Forcato Mattia, Oliveira Giacomo, Provasi Elena et al. IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood. 2013; 121(4): 573-584. PubMed | Google Scholar

  23. Crompton Joseph, Sukumar Madhusudhanan, Restifo Nicholas. Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy. Immunol Rev. 2014; 257(1): 264-276. PubMed | Google Scholar

  24. Weng Xiufang, Zhong Maohua, Liang Zhihui, Lu Shenjun, Hao Juan, Chen Xueling et al. Peptide-dependent inhibition of alloreactive T-cell response by soluble divalent HLA-A2/IgG molecule in vitro. transplantation. 2007; 84(10): 1298-1306. PubMed | Google Scholar

  25. McCoy J Philip. Handling, storage and preparation of human blood cells. Curr Prot Cytom. 1998; 5(5.1): 1-13. PubMed | Google Scholar

  26. Johnson Simon, Nguyen Vy, Coder David. Assessment of Cell Viability. Curr Protoc Cytom. 2013; Chapter 9: Unit9.2. PubMed | Google Scholar

  27. Coder David. Assessment of cell viability. Curr Prot Cytom. 2001; 15(9.2): 1-14. PubMed | Google Scholar

  28. Butterfield Lisa, Koh Andrew, Meng Wilson, Vollmer Charles, Ribas Antoni, Dissette Vivian et al. Generation of human T-cell responses to an HLA-A2, 1-restricted peptide epitope derived from a-fetoprotein. Cancer Res. 1999 Jul 1; 59(13): 3134-42. Google Scholar

  29. Butterfield Lisa, Meng Wilson, Koh Andrew, Vollmer Charles, Ribas Antoni, Dissette Vivian et al. T Cell Responses to HLA-A*0201-Restricted peptides derived from human alpha fetoprotein. J Immunol. 2001 Apr 15; 166(8): 5300-8. PubMed | Google Scholar

  30. Pearce Erika. Metabolism in T cell activation and differentiation. Curr Opin Immunol. 2010; 22(3): 314-320. PubMed | Google Scholar

  31. Pearce Erika, Walsh Matthew, Cejas Pedro, Harms Gretchen, Shen Hao, Wang San et al. Enhancing CD8 T Cell Memory by Modulating Fatty Acid Metabolism. Nature. 2009; 460(7251): 103-107. PubMed | Google Scholar

  32. Benjamin Don, Colombi Marco, Moroni Christoph, Hall Michael. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov. 2011; 10(November): 868-880. PubMed | Google Scholar

  33. Araki Koichi, Youngblood Ben, Ahmed Rafi. The role of mTOR in memory CD8+ T-cell differentiation. Immunol Rev. 2010; 235(1): 234-243. PubMed | Google Scholar

  34. Huang Jian, Nguyen-McCarty Michelle, Hexner Elizabeth, Danet-Desnoyers Gwen, Klein Peter. Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR Pathways. Nat Med. 2012; 18(12): 1778-1785. PubMed | Google Scholar

  35. Zheng Yan, Collins Samuel, Lutz Michael, Allen Amy, Kole Thomas, Zarek Paul et al. A role for mammalian target of rapamycin in regulating T Cell activation versus anergy. J Immunol. 2007; 178: 2163-2170. PubMed | Google Scholar

  36. Zheng Yan, Delgoffe Greg, Meyer Christian, Chan Waipan, Powell Jonathan. Anergic T Cells are metabolically anergic. J Immunol. 2009; 183(10): 6095-6101. PubMed | Google Scholar

  37. Yi John, Ingram Jennifer, Zajac Allan. IL-21-deficiency Influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol. 2010; 185(8): 4835-4845. PubMed | Google Scholar

  38. Fröhlich Anja, Kisielow Jan, Schmitz Iwana, Freigang Stefan, Shamshiev Abdijapar, Weber Jacqueline et al. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science. 2009; 324: 1576-1580. PubMed | Google Scholar

  39. Elsaesser Heidi, Sauer Karsten, Brooks David. IL-21 is required to control chronic viral infection. Science. 2009; 324(5934): 1569-1572. PubMed | Google Scholar