References

  1. Winkler A S, Katrin Friedrich, Rebekka Konig, Michael Meindl, Raimund Helbok, Iris Unterberger, Thaddaeus Gotwald, Jaffer Dharsee, Sandeep Velicheti, Aslam Kidunda, Louise Jilek-Aall, William Matuja, and Erich Schmutzhard. The head nodding syndrome-Clinical classification and possible causes. Epilepsia. 2008; 49 (12):2008-2015. PubMed | Google Scholar

  2. Nyungura JL, Akim T, Lako A, Gordon A, Lejeng L, William G. Investigation into nodding syndrome in Witto Payam, Western Equatoria State. Southern Sudan Medical Journal. 2011; 4(1):3-6. PubMed | Google Scholar

  3. Sejvar JJ, Kakooza AM, Foltz JL, Makumbi I, Atai-Omoruto AD, Malimbo M, Ndyomugyenyi R, Alexander LN, Abang B, Downing RG, Ehrenberg A, Guilliams K, Helmers S, Melstrom P, Olara D, Perlman S, Ratto J, Trevathan E, Winkler AS, Dowell SF, Lwamafa D. Clinical, neurologic, and electrophysiologic features of nodding syndrome, Kitgum, Uganda an observational case series. Lancet Neurol. 2013; 12(2):166-74. PubMed | Google Scholar

  4. Lacey M. Nodding disease: mystery of southern Sudan. Lancet neurology. 2003; 2(12):714. PubMed | Google Scholar

  5. Dhossche D, Kakooza-Mwesige A. Nodding Syndrome in Ugandan Children and Adolescents: Menage A Trois of Epilepsy, Autism, and Pediatric Catatonia. Autism. 2012; 2(3):1-2. PubMed | Google Scholar

  6. Musisi S, Akena D, Nakimuli-Mpungu E, Abbo C, Okello J. Neuropsychiatric perspectives on nodding syndrome in northern Uganda: a case series study and a review of the literature. African Health sciences. 2013; 13(2):205- 218. PubMed | Google Scholar

  7. Idro R, Opoka RO, Aanyu HT et al. Nodding syndrome in Ugandan children-clinical features, brain imaging and complications: a case series. BMJ Open. 2013; 3(5):1 - 11. PubMed | Google Scholar

  8. Wadman Meredith. African outbreak stumps experts. Nature. 2011; 475(7355):148-149. PubMed | Google Scholar

  9. Lul Reik, Abdinasir Abubakar, Martin Opoka, Godwin Mindra, James Sejvar, Scott F. Dowell, Carlos Navarro-Colorado, Curtis Blanton, Jeffrey Ratto, Sudhir Bunga and Jennifer Foltz. Nodding Syndrome-South Sudan, 2011 MMWR. 2012; 61(3):52-54. PubMed | Google Scholar

  10. Foltz JL, Makumbi I, Sejvar JJ, Malimbo M, Ndyomugyenyi R, Atai-Omoruto AD, Alexander LN, Abang B, Melstrom P, Kakooza AM, Olara D, Downing RG, Nutman TB, Dowell SF, Lwamafa DK. An Epidemiologic Investigation of Potential Risk Factors for Nodding Syndrome in Kitgum District, Uganda. PLoS ONE. 2013; 8(6):1-9. PubMed | Google Scholar

  11. Spencer PS, Vandemaele K, Richer M, Palmer VS, Chungong S, Anker M, Ayana Y, Opoka ML, Klaucke BN, Quarello A, Tumwine JK. Nodding syndrome in Mundri county, South Sudan: environmental, nutritional and infectious factors. African Health Sciences. 2013; 13(2):183-204. PubMed | Google Scholar

  12. WHO. Uganda: Nodding disease (Situation as of 14 February, 2012). Downloaded on. 20/09/2012 from. PubMed | Google Scholar

  13. Yess N, Price J M, Brown R R, Swan P B and Linkswiler H. Vitamin B6 Depletion in Man: Urinary Excretion of Tryptophan Metabolites. J Nutr. 1964; 84(64):229-236. PubMed | Google Scholar

  14. Lee Hyun Jung, Jae-Hyung Bach, Hee-Sun Chae, Sang Hyung Lee, Wan Seok Joo, Se Hoon Choi, Kyung Yong Kim, Won Bok Lee and Sung Su Kim. Mitogen-activated protein kinase/extracellular signal-regulated kinase attenuates 3-hydroxykynurenine-induced neuronal cell death. International Society for Neurochemistry. J Neurochem. 2004; 88(3):647-656. PubMed | Google Scholar

  15. World Health Organization. Health Research Methodology: a Guide for Training in Research Methods. 2nd Ed Regional Office for the Western Pacific, Manila. 2001; 78-79. PubMed | Google Scholar

  16. WHO. International Scientific Meeting on Nodding Syndrome. 2012; 1-42. Downloaded on 12/02/2013. PubMed | Google Scholar

  17. My BioSource material datasheet for Human 3-hydroxykynurenine (3-HK). ELISA Kit. lot number MBS704658. Google Scholar

  18. MyBioSource material datasheet for Human Vitamin B6(VB6).ELISA Kit. lot number MBS163853. Google Scholar

  19. Daniel Hyams. CurveExpert Copyright ©. 1995-2007. Google Scholar

  20. Korevaar DA and Visser BJ. Reviewing the evidence on nodding syndrome, a mysterious tropical disorder. Int J Infect Dis. 2013; 17(3):149-152. PubMed | Google Scholar

  21. Idro R, Musubire K A, Byamah Mutamba B, Namusoke H, Muron J, Abbo C, Oriyabuzu R, Ssekyewa J, Okot C, Mwaka D, Ssebadduka P, Makumbi I, Opar B, Aceng JR, Mbonye AK (2013). Proposed guidelines for the management of nodding syndrome. African Health Sciences. 2013; 13(2):219-232. PubMed | Google Scholar

  22. United Nations System. Standing Committee on Nutrition. Nutrition Information in Crisis Situations - Uganda. Downloaded on 20/02/2015 from. Google Scholar

  23. EUROPEAN COMMISSION HUMANITARIAN AID OFFICE (ECHO) Humanitarian Aid Decision F9 (FED 9): Humanitarian aid in favour of the people of Uganda to relieve vulnerable population groups affected by insecurity and climatic hazards. ECHO/UGA/EDF/2004/01000. Downloaded on 20/02/2015 from. Google Scholar

  24. AVSI & UNHCR. Finding durable solutions in Northern Uganda. Downloaded on 20/02/2015 from. Google Scholar

  25. Bauernfeind JC and ON Miller1978, Vitamin B6: Nutritional and pharmaceutical usage, stability, bioavailability, antagonists, and safety: Pp. 78-110 in Human Vitamin B6 Requirements. Proceedings of a Workshop, June 11-12, 1976. Letterman Army Institute of Research, Presidio of San Francisco, California. A Report of the Committee on Dietary Allowances, Food and Nutrition Board. National Academy of Sciences, Washington, DC. PubMed | Google Scholar

  26. National Institute of Health office of Dietary Supplements. Vitamin B6 Dietary Supplement Fact Sheet. Downloaded on 20/02/2015 from. Google Scholar

  27. Theofylaktopoulou D, Ulvik A, Midttun Ø, Ueland PM, Vollset SE, Nygård O, Hustad S, Tell GS, Eussen SJ. Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-?-mediated immune activation in the community-based Hordaland Health Study. Br J Nutr. 2014; 112(7):1065-72. PubMed | Google Scholar

  28. ROSE D P. Aspects of tryptophan metabolism in health and disease: a review. J clin Path. 1972; 25(1):17-25. PubMed | Google Scholar

  29. Yeh K, James and Brown R, Raymond. Effects of Vitamin B-6 Deficiency and Tryptophan Loading on Urinary Excretion of Tryptophan Metabolites in Mammals. J Nutr. 1977; 107(2):261-271. PubMed | Google Scholar

  30. Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith QR. Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem. 1991; 56(6):2007-2017. PubMed | Google Scholar

  31. Ogawa T, Matson W R, Beal M F, Myers R H, Bird E D, Milbury P and Saso S. Kynurenine pathway abnormalities in Parkinson?s disease. Neurology. 1992; 42(9): 1702-1706. PubMed | Google Scholar

  32. Sardar A M, Bell J E and Reynolds G P. Increased concentrations of the neurotoxin 3-hydroxykynurenine in the frontal cortex of HIV-1-positive patients. J Neurochem. 1995; 64 (2):932-935. PubMed | Google Scholar

  33. Markus J Schwarz, Gilles J Guillemin, Stefan J Teipel, Katharina Buerger and Harald Hampel. Increased 3-Hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls. Eur Arch Psychiatry Clin Neurosci. 2012; 263(4):345 - 352. PubMed | Google Scholar

  34. Dalgliesh C E and Tekman S. The Excretion of Kynurenine and 3-Hydroxykynurenine by Man. Postgraduate Medical School, London, W 12. 1953; 56(3):459- 463. PubMed | Google Scholar
  35. Nishizuka, Y and Hayaishi, 0. Studies on the Biosynthesis of NicotinamideAdenine Dinucleotide: I Enzymic synthesis of niacin ribonucleotides from 3-hydroxyanthranilic acid in mammalian tissues. JBiol Chem. 1963; 238 (10):3369 - 3377. PubMed | Google Scholar