References

  1. Ayuk John, Sheppard Michael C. Does acromegaly enhance mortality?. Rev Endocr Metab Disord. 2008; 9: 33-39. This article on PubMed

  2. Mestron A, Webb SM, Astorga R, Benito P, Catala M, Gaztambide S, et al. Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA). Eur J Endocrinol. 2004 Oct;151(4):439-46. This article on PubMed

  3. Brada M, Ashley S, Ford D, Traish D, Burchell L, Rajan B. Cerebrovascular mortality in patients with pituitary adenoma. Clin Endocrinol (Oxf). 2002 Dec;57(6):713-7. This article on PubMed

  4. Kauppinen-Mäkelin R, Sane T, Välimäki MJ, Markkanen H, et al. Increased cancer incidence in acromegaly - a nationwide survey. Clin Endocrinol (Oxf). 2010 Feb;72(2):278-9. This article on PubMed

  5. Orme Stephen M, Mcnally Richard JQ, Cartwright Ray A et al. Mortality and Cancer Incidence in acromegaly: A retrospective Cohort Study - United Kingdom Acromegaly Study Group. J Clin Endocrinol Metab. 1998; 83: 2730-2734. This article on PubMed

  6. Popovic V, Damjanovic S, Micic D, Nesovic M, Djurovic M, et al. Increased incidence of neoplasia in patients with pituitary adenomas. The Pituitary Study Group. Clin Endocrinol (Oxf). 1998 Oct;49(4):441-5. This article on PubMed

  7. Baldys-Waligórska A, Krzentowska A, Golkowski F, et al. The prevalence of benign and malignant neoplasms in acromegalic patients. Endokrynol Pol. 2010 Jan-Feb;61(1):29-34. This article on PubMed

  8. Yamaguchi M, Tate G, Yoshizawa Y, Midorikawa T, Sanada Y, Kumada K. Hepatocellular carcinoma in a patient with acromegaly and high serum levels of insulin-like growth factor I: report of a case. Surg Today. 2002;32(11):1008-11. This article on PubMed

  9. Jenkins PJ, Frajese V, Jones AM, Camacho-Hubner C, et al. Insulin-like growth factor I and the development of colorectal neoplasia in acromegaly. J Clin Endocrinol Metab. 2000 Sep;85(9):3218-21. This article on PubMed

  10. Loeper S, Ezzat S. Acromegaly: re-thinking the cancer risk. Rev Endocr Metab Disord. 2008 Mar;9(1):41-58. This article on PubMed

  11. Dworakowska Dorota, Gueorguiev Maria, Kelly Paul, Monson John P, Besser G Michael, Chew Shern L et al. Repeated colonoscopic screening of patients with acromegaly: 15-year experience identifies those at risk of new colonic neoplasia and allows for effective screening guidelines. European Journal of Endocrinology. 2010; 163: 21-28. This article on PubMed

  12. Higuchi Yoshinori, Saeki Noakatsu, Iuchi Toshihiko, Uchino Yoshio, Tatsuno Ichiro, Uchida Daigaku, Tanaka Tomoaki et al. Incidence of Malignant Tumors in Patients with Acromegaly. Endocrine Journal. 2000; 47(Suppl): S57-S60. This article on PubMed

  13. Tita P, Ambrosio Maria Rosaria, Scollo Claudia et al. High prevalence of differentiated thyroid carcinoma in acromegaly. Clin Endocrinol (Oxf). 2005; 63: 161-167. This article on PubMed

  14. Norberg Lars, Johansson Robert and Rasmuson Torgny. Pituitary adenomas in northern Sweden: a study on therapy choices and the risk of second primary tumours. Clinical Endocrinology. 2008; 68: 780-785. This article on PubMed

  15. Scacchi Massimo, Cavagnini Fransesco. Acromegaly. Pituitary. 2006; 9: 297-303. This article on PubMed

  16. Miraki-Miloud Farideh, Jenkins Paul J, Fairclough Peter D, jordan Stefan, Bustin Stefan A, Jones Angela M et al. Increased levels of insulin-like-growth-factor binding protein 2 in sera and tumors from patients with colonic neoplasias with and without acromegaly. Clinical endocrinology. 2001; 54: 499-508. This article on PubMed

  17. Barris Daslu, Gridley Gloria, Ron Efrat et al. Acromegaly and cancer risk: a cohort study in Sweden and Denmark. Cancer Causes and Control. 2002; 13: 395-400. This article on PubMed

  18. Barzilay Joshua, Heatley Gerald J, Cushing Gary W. Benign and Malignant Tumors in Patients With Acromegaly. Arch Intern Med. 1991; 151: 1629-1632. This article on PubMed

  19. Kuromoto Makiko, Fukuda Izumi, Hizuka Naomi, Takano Kazue. The prevalence of benign and malignant tumors at a single institute. Endocrine Journal. 2008; 55(1): 67-71. This article on PubMed

  20. Gasperi Marianna, Martino Elena, Manetti Luca, Arosio Massimo, Porretti Silvia, Faglia Giovanni et al, Acromegaly Study Group of the Italian Society of Endocrinology. Prevalence of thyroid diseases in patients with acromegaly: results of an Italian multi-center study. J Endocrinol Invest. 2002 ; 25(3): 240-5. This article on PubMed

  21. Manousos Orestis, Souglakos John, Bosetti Cristina et al. IGF-I and IGFII in relation to colorectal cancer. Int J Cancer. 1999; 83: 15-17. This article on PubMed

  22. Ma J, Pollak M, Giovannucci E, Chan JM, Tao Y, Hennekens C, Stampfer MJ. A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men. Growth Horm IGF Res. 2000 Apr;10 Suppl A:S28-9. This article on PubMed

  23. Giovannucci Edward, Pollak Michael N, Platz Elizabeth A et al. A prospective study of plasma insulin-like growth factor-1 and binding protein-3 Acromegaly and risk of cancer 399 and risk of colorectal neoplasia in women. Cancer Epidemiol Biomarkers Prev. 2000; 9: 345-349. This article on PubMed

  24. American Cancer Society. Cancer reference information. Atlanta: American Cancer Society 2007

  25. Renehan AG, Brennan BM. Acromegaly, growth hormone and cancer risk. Best Pract Res Clin Endocrinol Metab. 2008 Aug;22(4):639-57. This article on PubMed

  26. Ron Efrat, Gridley Gloria, Hrubec Zdenec et al. Acromegaly and gastrointestinal cancer. Cancer. 1991; 68: 1673-1777. This article on PubMed

  27. Jaques Gabrielle, Rotsch Martin, Wegmann Carole et al. Production of immunoreactive insulin-like growth factor 1 and response to exogenous IGF-1 in small cell lung cancer lines. Exp Cell Res. 1988; 176: 336-343. This article on PubMed

  28. Rotsch M, Maasberg M, Erbil C, et al.Characterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines. J Cancer Res Clin Oncol. 1992;118(7):502-8. This article on PubMed

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