Upper extremity deep vein thrombosis (UEDVT) is rare, especially after benign trauma. We report the case of a 31-year-old male nurse with UEDVT after elbow trauma with no fracture. This occupational accident caused thrombosis of basilica vein extended to humeral and axillary veins, collateral circulation in the arm and the right cervical and axillary regions. Thrombophilic tests and assessment of malignant tumor were negative. Treatment by low molecular weight heparin (LMWH) then by vitamin K antagonists was conducted and evaluation by Doppler ultrasonography realized 18 months after trauma showed recanalization of basilica and humeral veins and thrombosis of axillary and subclavian veins. Management of occupational activity was prescribed including eviction of heavy loads handling and repetitive gestures of upper limbs.