Introduction: Breast cancer is the most common malignancy tumor amongst Malagasy women registered at the pathology unit of the “Institut Pasteur de Madagascar”. In Madagascar, there is no laboratory practicing hormone receptors' status on these tumors. Until now no study about hormone receptors' status of Malagasy women with invasive breast cancer was performed. So it will be the first study on this topic. The aim of this study was to determine hormone receptors' status in Malagasy women with invasive breast cancer.

Methods: This retrospective and descriptive study was based on patients' medical files from 2009 to 2011. It included all invasive breast cancer diagnosed in Malagasy women at the pathology laboratory located at the “Institut Pasteur de Madagascar”, in Antananarivo. Along this period this laboratory has sent paraffin blocks of invasive breast carcinoma in two pathological laboratories in France.

Results: Results: We collected 77 cases of invasive breast cancer along this period. The mean age was 48.8 +/- 10.7, ranging from 26 years to 70 years. There were 46.8 % (n = 36) women with progesterone receptor positive (PR+), 53.2 % (n = 41) with progesterone receptor negative (PR-). For the estrogen receptor, 61.0 % (n=47) were positive and 36.4 % (n = 28) were negative. ER+/PR+ represented 44.2 % (n=34); ER-/PR- 33.8 % (n = 26); ER +/ PR- 16.8 % (n = 13); ER-/PR+ and ER ?/PR- represented respectively 2.6 % (n = 2).

Conclusion: Patients in our study profiles important rate of ER-, PR- and a less important rate of ER+/PR+, PR+. These results suggest that more studies related to Hormone Receptor profiles should be conducted with Malagasy women having invasive breast cancer